8ev6 - Revision history

OCA at 11:33, 15 November 2023

OCA — Wed, 15 Nov 2023 11:33:41 GMT

←Older revision		Revision as of 11:33, 15 November 2023
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/RL2_THET8 RL2_THET8] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial (By similarity). Makes several contacts with the 16S rRNA (forming bridge B7b) in the 70S ribosome.[HAMAP-Rule:MF_01320_B]		[https://www.uniprot.org/uniprot/RL2_THET8 RL2_THET8] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial (By similarity). Makes several contacts with the 16S rRNA (forming bridge B7b) in the 70S ribosome.[HAMAP-Rule:MF_01320_B]
		+
		+	==See Also==
		+	*[[Ribosomal protein THX 3D structures\|Ribosomal protein THX 3D structures]]
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:26, 9 August 2023

OCA — Wed, 09 Aug 2023 05:26:53 GMT

←Older revision		Revision as of 05:26, 9 August 2023
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-	'''Unreleased structure'''

-	~~The entry 8ev6 is ON HOLD until Paper Publication~~	+	==Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs==
-		+	<StructureSection load='8ev6' size='340' side='right'caption='[[8ev6]], [[Resolution\|resolution]] 2.95Å' scene=''>
-	~~Authors: Seely, S.M., Gagnon, M.G.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ev6]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EV6 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.946Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0TD:(3S)-3-(METHYLSULFANYL)-L-ASPARTIC+ACID'>0TD</scene>, <scene name='pdbligand=2MA:2-METHYLADENOSINE-5-MONOPHOSPHATE'>2MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=2MU:2,5-DIMETHYLURIDINE-5-MONOPHOSPHATE'>2MU</scene>, <scene name='pdbligand=4OC:4N,O2-METHYLCYTIDINE-5-MONOPHOSPHATE'>4OC</scene>, <scene name='pdbligand=4SU:4-THIOURIDINE-5-MONOPHOSPHATE'>4SU</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=AKN:(2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S+,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide'>AKN</scene>, <scene name='pdbligand=M2G:N2-DIMETHYLGUANOSINE-5-MONOPHOSPHATE'>M2G</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MIA:2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5-MONOPHOSPHATE'>MIA</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Seely, S.M~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ev6 OCA], [https://pdbe.org/8ev6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ev6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ev6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ev6 ProSAT]</span></td></tr>
-	[[Category: Gagnon~~, M.G~~]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RL2_THET8 RL2_THET8] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial (By similarity). Makes several contacts with the 16S rRNA (forming bridge B7b) in the 70S ribosome.[HAMAP-Rule:MF_01320_B]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Thermus thermophilus HB8]]
		+	[[Category: Gagnon MG]]
		+	[[Category: Seely SM]]

OCA at 08:08, 24 November 2022

OCA — Thu, 24 Nov 2022 08:08:22 GMT

←Older revision		Revision as of 08:08, 24 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ev6 is ON HOLD	+	The entry 8ev6 is ON HOLD until Paper Publication

	Authors: Seely, S.M., Gagnon, M.G.		Authors: Seely, S.M., Gagnon, M.G.

OCA: Protected "8ev6" [edit=sysop:move=sysop]

OCA — Wed, 26 Oct 2022 04:06:55 GMT

Protected "8ev6" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:06, 26 October 2022

OCA: New page: '''Unreleased structure''' The entry 8ev6 is ON HOLD Authors: Seely, S.M., Gagnon, M.G. Description: Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin...

OCA — Wed, 26 Oct 2022 04:06:54 GMT

New page: '''Unreleased structure''' The entry 8ev6 is ON HOLD Authors: Seely, S.M., Gagnon, M.G. Description: Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin...

New page

'''Unreleased structure'''

The entry 8ev6 is ON HOLD

Authors: Seely, S.M., Gagnon, M.G.

Description: Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs
[[Category: Unreleased Structures]]
[[Category: Seely, S.M]]
[[Category: Gagnon, M.G]]