OCA at 07:04, 25 October 2023

OCA — Wed, 25 Oct 2023 07:04:18 GMT

←Older revision		Revision as of 07:04, 25 October 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8evo is ~~ON HOLD until Paper Publication~~	+	==Sulfatase from Mycobacterium tuberculosis (Rv3406) in complex with inhibitor FG2216==
-		+	<StructureSection load='8evo' size='340' side='right'caption='[[8evo]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8evo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EVO FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=UN9:N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE'>UN9</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8evo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8evo OCA], [https://pdbe.org/8evo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8evo RCSB], [https://www.ebi.ac.uk/pdbsum/8evo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8evo ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ATSK_MYCTU ATSK_MYCTU] Alpha-ketoglutarate-dependent sulfate ester dioxygenase, which oxidizes medium-chain alkyl-sulfate esters (PubMed:23762287). Shows preference for 2-ethylhexyl sulfate (2-EHS) in vitro, leading to the formation of succinate and 2-ethylhexanal (PubMed:23762287, PubMed:25427196). Has likely a role in sulfate scavenging in vivo (PubMed:23762287).<ref>PMID:23762287</ref> <ref>PMID:25427196</ref> Also causes the inactivation of the 2-carboxyquinoxaline Ty38c (an antitubercular compound that inhibits DprE1) via oxidative decarboxylation, using Ty38c instead of alpha-ketoglutarate as a substrate. Is thus responsible for primary resistance of M.tuberculosis to Ty38c in vitro. Overexpression of Rv3406 causes resistance to Ty38c.<ref>PMID:25427196</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Juan T-J]]
		+	[[Category: Leung I]]
		+	[[Category: Squire CJ]]

OCA at 05:22, 3 November 2022

OCA — Thu, 03 Nov 2022 05:22:39 GMT

←Older revision		Revision as of 05:22, 3 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8evo is ON HOLD	+	The entry 8evo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8evo" [edit=sysop:move=sysop]

OCA — Wed, 26 Oct 2022 04:07:40 GMT

Protected "8evo" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:07, 26 October 2022

OCA: New page: '''Unreleased structure''' The entry 8evo is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Oct 2022 04:07:39 GMT

New page: '''Unreleased structure''' The entry 8evo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8evo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8evo - Revision history

OCA at 07:04, 25 October 2023

OCA at 05:22, 3 November 2022

OCA: Protected "8evo" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8evo is ON HOLD Authors: Description: Category: Unreleased Structures