8ex8 - Revision history

OCA at 21:26, 28 June 2023

OCA — Wed, 28 Jun 2023 21:26:19 GMT

←Older revision		Revision as of 21:26, 28 June 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8ex8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EX8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8ex8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EX8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ex8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ex8 OCA], [https://pdbe.org/8ex8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ex8 RCSB], [https://www.ebi.ac.uk/pdbsum/8ex8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ex8 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.17Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ex8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ex8 OCA], [https://pdbe.org/8ex8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ex8 RCSB], [https://www.ebi.ac.uk/pdbsum/8ex8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ex8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 05:42, 31 May 2023

OCA — Wed, 31 May 2023 05:42:58 GMT

←Older revision		Revision as of 05:42, 31 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8ex8 is ~~ON HOLD until Paper Publication~~	+	==Human S1P transporter Spns2 in an outward-facing partially occluded conformation (state 2)==
-		+	<StructureSection load='8ex8' size='340' side='right'caption='[[8ex8]], [[Resolution\|resolution]] 4.17Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ex8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EX8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ex8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ex8 OCA], [https://pdbe.org/8ex8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ex8 RCSB], [https://www.ebi.ac.uk/pdbsum/8ex8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ex8 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/SPNS2_HUMAN SPNS2_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPNS2_HUMAN SPNS2_HUMAN] Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking (PubMed:19074308, PubMed:23180825, PubMed:21084291). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system (PubMed:19074308, PubMed:23180825). Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:19074308, PubMed:23180825). Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (By similarity). Also required for the egress of immature B-cells from the bone marrow (By similarity). In contrast, not involved in S1P release from red blood cells (By similarity). Involved in auditory function (PubMed:30973865). S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (By similarity). In addition to export, also able to mediate S1P import (By similarity).[UniProtKB:Q91VM4]<ref>PMID:19074308</ref> <ref>PMID:21084291</ref> <ref>PMID:23180825</ref> <ref>PMID:30973865</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Ahmed S]]
		+	[[Category: Dai Y]]
		+	[[Category: Lee CH]]
		+	[[Category: Zhao H]]

OCA at 08:33, 30 November 2022

OCA — Wed, 30 Nov 2022 08:33:59 GMT

←Older revision		Revision as of 08:33, 30 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ex8 is ON HOLD	+	The entry 8ex8 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8ex8" [edit=sysop:move=sysop]

OCA — Thu, 03 Nov 2022 05:25:39 GMT

Protected "8ex8" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:25, 3 November 2022

OCA: New page: '''Unreleased structure''' The entry 8ex8 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 03 Nov 2022 05:25:38 GMT

New page: '''Unreleased structure''' The entry 8ex8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ex8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]