8eyo - Revision history

OCA at 10:26, 25 October 2023

OCA — Wed, 25 Oct 2023 10:26:06 GMT

←Older revision		Revision as of 10:26, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8eyo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[8eyo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EYO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.49Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eyo OCA], [https://pdbe.org/8eyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eyo RCSB], [https://www.ebi.ac.uk/pdbsum/8eyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eyo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eyo OCA], [https://pdbe.org/8eyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eyo RCSB], [https://www.ebi.ac.uk/pdbsum/8eyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eyo ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 8eyo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 8eyo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[NADP-dependent malic enzyme\|NADP-dependent malic enzyme]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:48, 8 February 2023

OCA — Wed, 08 Feb 2023 06:48:27 GMT

←Older revision		Revision as of 06:48, 8 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8eyo is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of Human Mitochondrial NADP+ Malic Enzyme 3 with NADP bound==
		+	<StructureSection load='8eyo' size='340' side='right'caption='[[8eyo]], [[Resolution\|resolution]] 2.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8eyo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EYO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eyo OCA], [https://pdbe.org/8eyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eyo RCSB], [https://www.ebi.ac.uk/pdbsum/8eyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eyo ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MAON_HUMAN MAON_HUMAN] Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+) as a cofactor (PubMed:7818469). Can also reverse the decarboxylation reaction, but only with significantly lower efficiency (PubMed:7818469).<ref>PMID:7818469</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Malic enzymes (ME1, ME2, and ME3) are involved in cellular energy regulation, redox homeostasis, and biosynthetic processes, through the production of pyruvate and reducing agent NAD(P)H. Recent studies have implicated the third and least well-characterized isoform, mitochondrial NADP(+)-dependent malic enzyme 3 (ME3), as a therapeutic target for pancreatic cancers. Here, we utilized an integrated structure approach to determine the structures of ME3 in various ligand-binding states at near-atomic resolutions. ME3 is captured in the open form existing as a stable tetramer and its dynamic Domain C is critical for activity. Catalytic assay results reveal that ME3 is a non-allosteric enzyme and does not require modulators for activity while structural analysis suggests that the inner stability of ME3 Domain A relative to ME2 disables allostery in ME3. With structural information available for all three malic enzymes, the foundation has been laid to understand the structural and biochemical differences of these enzymes and could aid in the development of specific malic enzyme small molecule drugs.

-	~~Authors~~:	+	Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer.,Grell TAJ, Mason M, Thompson AA, Gomez-Tamayo JC, Riley D, Wagner MV, Steele R, Ortiz-Meoz RF, Wadia J, Shaffer PL, Tresadern G, Sharma S, Yu X Heliyon. 2022 Dec 19;8(12):e12392. doi: 10.1016/j.heliyon.2022.e12392. , eCollection 2022 Dec. PMID:36590518<ref>PMID:36590518</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8eyo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Grell TAJ]]
		+	[[Category: Mason M]]
		+	[[Category: Ortiz-Meoz R]]
		+	[[Category: Riley D]]
		+	[[Category: Shaffer PL]]
		+	[[Category: Sharma S]]
		+	[[Category: Steele R]]
		+	[[Category: Thompson AA]]
		+	[[Category: Wadia J]]
		+	[[Category: Wagner MV]]
		+	[[Category: Yu X]]

OCA at 05:28, 7 December 2022

OCA — Wed, 07 Dec 2022 05:28:35 GMT

←Older revision		Revision as of 05:28, 7 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8eyo is ON HOLD	+	The entry 8eyo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8eyo" [edit=sysop:move=sysop]

OCA — Wed, 09 Nov 2022 05:05:08 GMT

Protected "8eyo" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:05, 9 November 2022

OCA: New page: '''Unreleased structure''' The entry 8eyo is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 09 Nov 2022 05:05:07 GMT

New page: '''Unreleased structure''' The entry 8eyo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8eyo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]