8f0a - Revision history

OCA at 05:54, 5 July 2023

OCA — Wed, 05 Jul 2023 05:54:01 GMT

←Older revision		Revision as of 05:54, 5 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8f0a]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F0A FirstGlance]. <br>		<table><tr><td colspan='2'>[[8f0a]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F0A FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f0a OCA], [https://pdbe.org/8f0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f0a RCSB], [https://www.ebi.ac.uk/pdbsum/8f0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f0a ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f0a OCA], [https://pdbe.org/8f0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f0a RCSB], [https://www.ebi.ac.uk/pdbsum/8f0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f0a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:46, 21 June 2023

OCA — Wed, 21 Jun 2023 09:46:29 GMT

←Older revision		Revision as of 09:46, 21 June 2023
Line 8:		Line 8:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>		[https://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:16, 24 November 2022

OCA — Thu, 24 Nov 2022 10:16:05 GMT

←Older revision		Revision as of 10:16, 24 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8f0a ~~is ON HOLD~~	+	==Client-bound structure of a DegP trimer within a 12mer cage==
-		+	<StructureSection load='8f0a' size='340' side='right'caption='[[8f0a]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~: ~~Harkness~~, R.W., ~~Ripstein~~, Z.A., ~~Di Trani, J~~.M., ~~Kay, L~~.E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8f0a]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F0A FirstGlance]. <br>
-	~~Description~~: ~~Client-bound structure of~~ a DegP ~~trimer within~~ a ~~12mer cage~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f0a OCA], [https://pdbe.org/8f0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f0a RCSB], [https://www.ebi.ac.uk/pdbsum/8f0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f0a ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Kay, L.E~~]]	+	== Function ==
-	[[Category: ~~Ripstein, Z.A~~]]	+	[https://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>
-	[[Category: Harkness~~, R.W~~]]	+	== References ==
-	[[Category: ~~Di Trani, J.M~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli K-12]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Di Trani JM]]
		+	[[Category: Harkness RW]]
		+	[[Category: Kay LE]]
		+	[[Category: Ripstein ZA]]

OCA: Protected "8f0a" [edit=sysop:move=sysop]

OCA — Wed, 09 Nov 2022 05:08:54 GMT

Protected "8f0a" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:08, 9 November 2022

OCA: New page: '''Unreleased structure''' The entry 8f0a is ON HOLD Authors: Harkness, R.W., Ripstein, Z.A., Di Trani, J.M., Kay, L.E. Description: Client-bound structure of a DegP trimer within a 12...

OCA — Wed, 09 Nov 2022 05:08:53 GMT

New page: '''Unreleased structure''' The entry 8f0a is ON HOLD Authors: Harkness, R.W., Ripstein, Z.A., Di Trani, J.M., Kay, L.E. Description: Client-bound structure of a DegP trimer within a 12...

New page

'''Unreleased structure'''

The entry 8f0a is ON HOLD

Authors: Harkness, R.W., Ripstein, Z.A., Di Trani, J.M., Kay, L.E.

Description: Client-bound structure of a DegP trimer within a 12mer cage
[[Category: Unreleased Structures]]
[[Category: Kay, L.E]]
[[Category: Ripstein, Z.A]]
[[Category: Harkness, R.W]]
[[Category: Di Trani, J.M]]