8f27 - Revision history

OCA at 21:26, 28 June 2023

OCA — Wed, 28 Jun 2023 21:26:21 GMT

←Older revision		Revision as of 21:26, 28 June 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8f27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8f27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DA:2-DEOXY-L-RIBO-FURANOSYL+ADENOSINE-5-MONOPHOSPHATE'>0DA</scene>, <scene name='pdbligand=0DC:2-DEOXY-L-RIBO-FURANOSYL+CYTOSINE-5-MONOPHOSPHATE'>0DC</scene>, <scene name='pdbligand=0DG:2-DEOXY-L-RIBO-FURANOSYL+GUANINE-5-MONOPHOSPHATE'>0DG</scene>, <scene name='pdbligand=0DT:2-DEOXY-L-RIBO-FURANOSYL+THYMIDINE-5-MONOPHOSPHATE'>0DT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XEC:1-(2-O-methyl-5-O-phosphono-beta-L-ribofuranosyl)pyrimidine-2,4(1H,3H)-dione'>XEC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DA:2-DEOXY-L-RIBO-FURANOSYL+ADENOSINE-5-MONOPHOSPHATE'>0DA</scene>, <scene name='pdbligand=0DC:2-DEOXY-L-RIBO-FURANOSYL+CYTOSINE-5-MONOPHOSPHATE'>0DC</scene>, <scene name='pdbligand=0DG:2-DEOXY-L-RIBO-FURANOSYL+GUANINE-5-MONOPHOSPHATE'>0DG</scene>, <scene name='pdbligand=0DT:2-DEOXY-L-RIBO-FURANOSYL+THYMIDINE-5-MONOPHOSPHATE'>0DT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XEC:1-(2-O-methyl-5-O-phosphono-beta-L-ribofuranosyl)pyrimidine-2,4(1H,3H)-dione'>XEC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f27 OCA], [https://pdbe.org/8f27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f27 RCSB], [https://www.ebi.ac.uk/pdbsum/8f27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f27 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f27 OCA], [https://pdbe.org/8f27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f27 RCSB], [https://www.ebi.ac.uk/pdbsum/8f27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f27 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:32, 12 April 2023

OCA — Wed, 12 Apr 2023 20:32:53 GMT

←Older revision		Revision as of 20:32, 12 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8f27 is ~~ON HOLD until Paper~~ Publication	+	==Mirror-image DNA containing 2'-OMe-L-uridine residue==
		+	<StructureSection load='8f27' size='340' side='right'caption='[[8f27]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8f27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F27 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DA:2-DEOXY-L-RIBO-FURANOSYL+ADENOSINE-5-MONOPHOSPHATE'>0DA</scene>, <scene name='pdbligand=0DC:2-DEOXY-L-RIBO-FURANOSYL+CYTOSINE-5-MONOPHOSPHATE'>0DC</scene>, <scene name='pdbligand=0DG:2-DEOXY-L-RIBO-FURANOSYL+GUANINE-5-MONOPHOSPHATE'>0DG</scene>, <scene name='pdbligand=0DT:2-DEOXY-L-RIBO-FURANOSYL+THYMIDINE-5-MONOPHOSPHATE'>0DT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XEC:1-(2-O-methyl-5-O-phosphono-beta-L-ribofuranosyl)pyrimidine-2,4(1H,3H)-dione'>XEC</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f27 OCA], [https://pdbe.org/8f27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f27 RCSB], [https://www.ebi.ac.uk/pdbsum/8f27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f27 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To further expand the functionality and enhance the stability of mirror-image nucleic acid as advanced agent for basic research and therapeutic design, we have synthesized the 2'-deoxy2'-methoxy-L-uridine phosphoramidites and incorporate it into L-DNA and L-RNA via solid-phase synthesis quantitatively. We found that the thermostability of L-nucleic acids is dramatically improved after introducing the modifications. Moreover, we successfully crystallized both L-DNA and L-RNA duplexes containing the 2'-OMe modifications and sharing the identical sequence. The crystal structure determination and analysis reveal the overall structures of the mirrorimage nucleic acids, and for the first time interpretate the structural deviation caused by 2'-OMe and 2'-OH groups in the oligonucleotides which are highly similar. This novel chemical modification of nucleic acid has the potential to be used to design nucleic acid-based therapeutic and material in the future.

-	~~Authors: Zhang, W~~., Dantsu, Y.	+	Derivatization of Mirror-image L-Nucleic Acids with 2'-OMe Modification for Thermal and Structural Stabilization.,Dantsu Y, Zhang W Chembiochem. 2023 Mar 9:e202200764. doi: 10.1002/cbic.202200764. PMID:36892526<ref>PMID:36892526</ref>

-	~~Description: Mirror-image DNA containing 2''~~-~~OMe~~-~~L-uridine residue~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Dantsu, Y]]	+	<div class="pdbe-citations 8f27" style="background-color:#fffaf0;"></div>
-	[[Category: Zhang, W]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Dantsu Y]]
		+	[[Category: Zhang W]]

OCA at 08:09, 24 November 2022

OCA — Thu, 24 Nov 2022 08:09:35 GMT

←Older revision		Revision as of 08:09, 24 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f27 is ON HOLD	+	The entry 8f27 is ON HOLD until Paper Publication

	Authors: Zhang, W., Dantsu, Y.		Authors: Zhang, W., Dantsu, Y.

OCA: Protected "8f27" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2022 18:11:45 GMT

Protected "8f27" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:11, 16 November 2022

OCA: New page: '''Unreleased structure''' The entry 8f27 is ON HOLD Authors: Zhang, W., Dantsu, Y. Description: Mirror-image DNA containing 2''-OMe-L-uridine residue [[Category: Unreleased Structures...

OCA — Wed, 16 Nov 2022 18:11:44 GMT

New page: '''Unreleased structure''' The entry 8f27 is ON HOLD Authors: Zhang, W., Dantsu, Y. Description: Mirror-image DNA containing 2''-OMe-L-uridine residue [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 8f27 is ON HOLD

Authors: Zhang, W., Dantsu, Y.

Description: Mirror-image DNA containing 2''-OMe-L-uridine residue
[[Category: Unreleased Structures]]
[[Category: Dantsu, Y]]
[[Category: Zhang, W]]