OCA at 06:57, 27 September 2023

OCA — Wed, 27 Sep 2023 06:57:06 GMT

←Older revision		Revision as of 06:57, 27 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8f5q is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human PCNA in complex with the PIP box of FBH1==
		+	<StructureSection load='8f5q' size='340' side='right'caption='[[8f5q]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8f5q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F5Q FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f5q OCA], [https://pdbe.org/8f5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f5q RCSB], [https://www.ebi.ac.uk/pdbsum/8f5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f5q ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	F-box DNA helicase 1 (FBH1) is involved in the regulation of cell responses to replicative stress. FBH1 is recruited to stalled DNA replication fork by PCNA where it inhibits homologous recombination and catalyzes fork regression. Here, we report the structural basis for the molecular recognition of two distinctly different motifs of FBH1, FBH1(PIP) and FBH1(APIM), by PCNA. The crystal structure of PCNA in complex with FBH1(PIP) and analysis of NMR perturbations reveal overlapped FBH1(PIP) and FBH1(APIM) binding sites of PCNA and the dominant contribution of FBH1(PIP) in this interaction.

-	~~Authors~~:	+	Molecular insight into the PCNA-binding mode of FBH1.,Liu J, Chaves-Arquero B, Wei P, Tencer AH, Ruiz-Albor A, Zhang G, Blanco FJ, Kutateladze TG Structure. 2023 May 4;31(5):511-517.e3. doi: 10.1016/j.str.2023.03.004. Epub 2023 , Mar 28. PMID:36990095<ref>PMID:36990095</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8f5q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Blanco F]]
		+	[[Category: Chaves-Arquero B]]
		+	[[Category: Kutateladze T]]
		+	[[Category: Liu J]]
		+	[[Category: Tencer H]]
		+	[[Category: Wei P]]
		+	[[Category: Zhang G]]

OCA at 07:37, 14 December 2022

OCA — Wed, 14 Dec 2022 07:37:43 GMT

←Older revision		Revision as of 07:37, 14 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f5q is ON HOLD	+	The entry 8f5q is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8f5q" [edit=sysop:move=sysop]

OCA — Thu, 24 Nov 2022 08:14:03 GMT

Protected "8f5q" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:14, 24 November 2022

OCA: New page: '''Unreleased structure''' The entry 8f5q is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 24 Nov 2022 08:14:02 GMT

New page: '''Unreleased structure''' The entry 8f5q is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8f5q is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8f5q - Revision history

OCA at 06:57, 27 September 2023

OCA at 07:37, 14 December 2022

OCA: Protected "8f5q" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8f5q is ON HOLD Authors: Description: Category: Unreleased Structures