8f5y - Revision history

OCA at 08:54, 21 February 2024

OCA — Wed, 21 Feb 2024 08:54:31 GMT

←Older revision		Revision as of 08:54, 21 February 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8f5y is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1==
-		+	<StructureSection load='8f5y' size='340' side='right'caption='[[8f5y]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~Authors~~: ~~Huber~~, A.D., ~~Poudel~~, S., ~~Seetharaman, J~~., ~~Miller, D~~.J., ~~Chen, T~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8f5y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F5Y FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of pregnane X~~ receptor ~~ligand binding domain complexed with JQ1~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene></td></tr>
-	[[Category: ~~Huber, A.D~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f5y OCA], [https://pdbe.org/8f5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f5y RCSB], [https://www.ebi.ac.uk/pdbsum/8f5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f5y ProSAT]</span></td></tr>
-	[[Category: Chen, T]]	+	</table>
-	[[Category: ~~Poudel, S~~]]	+	== Function ==
-	[[Category: Miller~~, D.J~~]]	+	[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
-	[[Category: Seetharaman, J]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen T]]
		+	[[Category: Huber AD]]
		+	[[Category: Miller DJ]]
		+	[[Category: Poudel S]]
		+	[[Category: Seetharaman J]]

OCA at 08:43, 20 December 2023

OCA — Wed, 20 Dec 2023 08:43:39 GMT

←Older revision		Revision as of 08:43, 20 December 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f5y is ON HOLD	+	The entry 8f5y is ON HOLD until Paper Publication

	Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.		Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Huber, A.D]]		[[Category: Huber, A.D]]
		+	[[Category: Chen, T]]
	[[Category: Poudel, S]]		[[Category: Poudel, S]]
	[[Category: Miller, D.J]]		[[Category: Miller, D.J]]
-	[[Category: Chen, T]]
	[[Category: Seetharaman, J]]		[[Category: Seetharaman, J]]

OCA at 06:09, 29 November 2023

OCA — Wed, 29 Nov 2023 06:09:46 GMT

←Older revision		Revision as of 06:09, 29 November 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f5y is ON HOLD ~~until Paper Publication~~	+	The entry 8f5y is ON HOLD

	Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.		Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Huber, A.D]]		[[Category: Huber, A.D]]
-	[[Category: Chen, T]]
	[[Category: Poudel, S]]		[[Category: Poudel, S]]
	[[Category: Miller, D.J]]		[[Category: Miller, D.J]]
		+	[[Category: Chen, T]]
	[[Category: Seetharaman, J]]		[[Category: Seetharaman, J]]

OCA at 02:19, 25 May 2023

OCA — Thu, 25 May 2023 02:19:06 GMT

←Older revision		Revision as of 02:19, 25 May 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f5y is ON HOLD	+	The entry 8f5y is ON HOLD until Paper Publication

	Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.		Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Huber, A.D]]		[[Category: Huber, A.D]]
		+	[[Category: Chen, T]]
	[[Category: Poudel, S]]		[[Category: Poudel, S]]
	[[Category: Miller, D.J]]		[[Category: Miller, D.J]]
-	[[Category: Chen, T]]
	[[Category: Seetharaman, J]]		[[Category: Seetharaman, J]]

OCA at 14:49, 26 April 2023

OCA — Wed, 26 Apr 2023 14:49:41 GMT

←Older revision		Revision as of 14:49, 26 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f5y is ON HOLD ~~until Paper Publication~~	+	The entry 8f5y is ON HOLD

	Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.		Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.
Line 7:		Line 7:
	Description: Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1		Description: Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Huber, A.D]]
	[[Category: Poudel, S]]		[[Category: Poudel, S]]
	[[Category: Miller, D.J]]		[[Category: Miller, D.J]]
-	[[Category: Huber, A.D]]
	[[Category: Chen, T]]		[[Category: Chen, T]]
	[[Category: Seetharaman, J]]		[[Category: Seetharaman, J]]

OCA at 04:55, 25 January 2023

OCA — Wed, 25 Jan 2023 04:55:56 GMT

←Older revision		Revision as of 04:55, 25 January 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f5y is ON HOLD	+	The entry 8f5y is ON HOLD until Paper Publication

	Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.		Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.

OCA at 05:47, 28 December 2022

OCA — Wed, 28 Dec 2022 05:47:07 GMT

←Older revision		Revision as of 05:47, 28 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f5y is ON HOLD ~~until Paper Publication~~	+	The entry 8f5y is ON HOLD

	Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.		Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.
Line 7:		Line 7:
	Description: Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1		Description: Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Huber, A.D]]
	[[Category: Poudel, S]]		[[Category: Poudel, S]]
	[[Category: Miller, D.J]]		[[Category: Miller, D.J]]
		+	[[Category: Huber, A.D]]
	[[Category: Chen, T]]		[[Category: Chen, T]]
	[[Category: Seetharaman, J]]		[[Category: Seetharaman, J]]

OCA at 06:29, 21 December 2022

OCA — Wed, 21 Dec 2022 06:29:04 GMT

←Older revision		Revision as of 06:29, 21 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f5y is ON HOLD	+	The entry 8f5y is ON HOLD until Paper Publication

	Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.		Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.

OCA: Protected "8f5y" [edit=sysop:move=sysop]

OCA — Thu, 24 Nov 2022 08:14:29 GMT

Protected "8f5y" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:14, 24 November 2022

OCA: New page: '''Unreleased structure''' The entry 8f5y is ON HOLD Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T. Description: Crystal structure of pregnane X receptor lig...

OCA — Thu, 24 Nov 2022 08:14:28 GMT

New page: '''Unreleased structure''' The entry 8f5y is ON HOLD Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T. Description: Crystal structure of pregnane X receptor lig...

New page

'''Unreleased structure'''

The entry 8f5y is ON HOLD

Authors: Huber, A.D., Poudel, S., Seetharaman, J., Miller, D.J., Chen, T.

Description: Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1
[[Category: Unreleased Structures]]
[[Category: Huber, A.D]]
[[Category: Poudel, S]]
[[Category: Miller, D.J]]
[[Category: Chen, T]]
[[Category: Seetharaman, J]]