OCA at 08:23, 16 August 2023

OCA — Wed, 16 Aug 2023 08:23:11 GMT

←Older revision		Revision as of 08:23, 16 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8fac is ~~ON HOLD until Paper~~ Publication	+	==Structure of the leucine-rich repeat kinase 1 monomer==
		+	<StructureSection load='8fac' size='340' side='right'caption='[[8fac]], [[Resolution\|resolution]] 3.92Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8fac]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FAC FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.92Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fac OCA], [https://pdbe.org/8fac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fac RCSB], [https://www.ebi.ac.uk/pdbsum/8fac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fac ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/LRRK1_HUMAN LRRK1_HUMAN] Osteosclerotic metaphyseal dysplasia. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LRRK1_HUMAN LRRK1_HUMAN] Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.[UniProtKB:Q3UHC2]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human leucine-rich repeat kinases (LRRKs), LRRK1 and LRRK2 are large and unusually complex multi-domain kinases, which regulate fundamental cellular processes and have been implicated in human disease. Structures of LRRK2 have recently been determined, but the structure and molecular mechanisms regulating the activity of the LRRK1 as well as differences in the regulation of LRRK1 and LRRK2 remain unclear. Here, we report a cryo-EM structure of the LRRK1 monomer and a lower-resolution cryo-EM map of the LRRK1 dimer. The monomer structure, in which the kinase is in an inactive conformation, reveals key interdomain interfaces that control kinase activity as we validate experimentally. Both the LRRK1 monomer and dimer are structurally distinct compared to LRRK2. Overall, our results provide structural insights into the activation of the human LRRKs, which advance our understanding of their physiological and pathological roles.

-	~~Authors~~:	+	Structure and regulation of full-length human leucine-rich repeat kinase 1.,Metcalfe RD, Martinez Fiesco JA, Bonet-Ponce L, Kluss JH, Cookson MR, Zhang P Nat Commun. 2023 Aug 9;14(1):4797. doi: 10.1038/s41467-023-40532-2. PMID:37558661<ref>PMID:37558661</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8fac" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Martinez Fiesco JA]]
		+	[[Category: Metcalfe RD]]
		+	[[Category: Zhang P]]

OCA at 04:24, 2 March 2023

OCA — Thu, 02 Mar 2023 04:24:17 GMT

←Older revision		Revision as of 04:24, 2 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fac is ON HOLD	+	The entry 8fac is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 10:01, 22 February 2023

OCA — Wed, 22 Feb 2023 10:01:37 GMT

←Older revision		Revision as of 10:01, 22 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fac is ON HOLD ~~until Paper Publication~~	+	The entry 8fac is ON HOLD

	Authors:		Authors:

OCA: Protected "8fac" [edit=sysop:move=sysop]

OCA — Wed, 07 Dec 2022 05:33:43 GMT

Protected "8fac" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:33, 7 December 2022

OCA: New page: '''Unreleased structure''' The entry 8fac is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 07 Dec 2022 05:33:42 GMT

New page: '''Unreleased structure''' The entry 8fac is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8fac is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

8fac - Revision history

OCA at 08:23, 16 August 2023

OCA at 04:24, 2 March 2023

OCA at 10:01, 22 February 2023

OCA: Protected "8fac" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8fac is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures