OCA at 10:47, 22 May 2024

OCA — Wed, 22 May 2024 10:47:08 GMT

←Older revision		Revision as of 10:47, 22 May 2024
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 8faf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 8faf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Synaptotagmin 3D structures\|Synaptotagmin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:13, 19 July 2023

OCA — Wed, 19 Jul 2023 06:13:30 GMT

←Older revision		Revision as of 06:13, 19 July 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8faf is ~~ON HOLD until Paper~~ Publication	+	==Unedited Octopus bimaculoides Synaptotagmin 1 C2A at room temperature==
		+	<StructureSection load='8faf' size='340' side='right'caption='[[8faf]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8faf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Octopus_bimaculoides Octopus bimaculoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FAF FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8faf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8faf OCA], [https://pdbe.org/8faf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8faf RCSB], [https://www.ebi.ac.uk/pdbsum/8faf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8faf ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0L8IHK9_OCTBM A0A0L8IHK9_OCTBM]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In poikilotherms, temperature changes challenge the integration of physiological function. Within the complex nervous systems of the behaviorally sophisticated coleoid cephalopods, these problems are substantial. RNA editing by adenosine deamination is a well-positioned mechanism for environmental acclimation. We report that the neural proteome of Octopus bimaculoides undergoes massive reconfigurations via RNA editing following a temperature challenge. Over 13,000 codons are affected, and many alter proteins that are vital for neural processes. For two highly temperature-sensitive examples, recoding tunes protein function. For synaptotagmin, a key component of Ca(2+)-dependent neurotransmitter release, crystal structures and supporting experiments show that editing alters Ca(2+) binding. For kinesin-1, a motor protein driving axonal transport, editing regulates transport velocity down microtubules. Seasonal sampling of wild-caught specimens indicates that temperature-dependent editing occurs in the field as well. These data show that A-to-I editing tunes neurophysiological function in response to temperature in octopus and most likely other coleoids.

-	~~Authors: McNeme, S~~., Dominguez, ~~M.J.~~, ~~Birk~~, ~~M.A.~~, ~~Rosenthal~~, ~~J.C.~~, Sutton, R.B.	+	Temperature-dependent RNA editing in octopus extensively recodes the neural proteome.,Birk MA, Liscovitch-Brauer N, Dominguez MJ, McNeme S, Yue Y, Hoff JD, Twersky I, Verhey KJ, Sutton RB, Eisenberg E, Rosenthal JJC Cell. 2023 Jun 8;186(12):2544-2555.e13. doi: 10.1016/j.cell.2023.05.004. Epub , 2023 Jun 8. PMID:37295402<ref>PMID:37295402</ref>

-	~~Description~~: ~~Unedited Octopus bimaculoides Synaptotagmin 1 C2A at room temperature~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Rosenthal, J.C~~]]	+	<div class="pdbe-citations 8faf" style="background-color:#fffaf0;"></div>
-	[[Category: Birk~~, M.A~~]]	+	== References ==
-	[[Category: ~~Sutton, R.B~~]]	+	<references/>
-	[[Category: ~~Mcneme,~~ S]]	+	__TOC__
-	[[Category: ~~Dominguez, M.J~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Octopus bimaculoides]]
		+	[[Category: Birk MA]]
		+	[[Category: Dominguez MJ]]
		+	[[Category: McNeme S]]
		+	[[Category: Rosenthal JC]]
		+	[[Category: Sutton RB]]

OCA at 05:47, 11 January 2023

OCA — Wed, 11 Jan 2023 05:47:10 GMT

←Older revision		Revision as of 05:47, 11 January 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8faf is ON HOLD	+	The entry 8faf is ON HOLD until Paper Publication

	Authors: McNeme, S., Dominguez, M.J., Birk, M.A., Rosenthal, J.C., Sutton, R.B.		Authors: McNeme, S., Dominguez, M.J., Birk, M.A., Rosenthal, J.C., Sutton, R.B.

OCA: Protected "8faf" [edit=sysop:move=sysop]

OCA — Wed, 07 Dec 2022 05:33:59 GMT

Protected "8faf" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:33, 7 December 2022

OCA: New page: '''Unreleased structure''' The entry 8faf is ON HOLD Authors: McNeme, S., Dominguez, M.J., Birk, M.A., Rosenthal, J.C., Sutton, R.B. Description: Unedited Octopus bimaculoides Synaptot...

OCA — Wed, 07 Dec 2022 05:33:58 GMT

New page: '''Unreleased structure''' The entry 8faf is ON HOLD Authors: McNeme, S., Dominguez, M.J., Birk, M.A., Rosenthal, J.C., Sutton, R.B. Description: Unedited Octopus bimaculoides Synaptot...

New page

'''Unreleased structure'''

The entry 8faf is ON HOLD

Authors: McNeme, S., Dominguez, M.J., Birk, M.A., Rosenthal, J.C., Sutton, R.B.

Description: Unedited Octopus bimaculoides Synaptotagmin 1 C2A at room temperature
[[Category: Unreleased Structures]]
[[Category: Rosenthal, J.C]]
[[Category: Birk, M.A]]
[[Category: Sutton, R.B]]
[[Category: Mcneme, S]]
[[Category: Dominguez, M.J]]

8faf - Revision history

OCA at 10:47, 22 May 2024

OCA at 06:13, 19 July 2023

OCA at 05:47, 11 January 2023

OCA: Protected "8faf" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8faf is ON HOLD Authors: McNeme, S., Dominguez, M.J., Birk, M.A., Rosenthal, J.C., Sutton, R.B. Description: Unedited Octopus bimaculoides Synaptot...