OCA at 08:17, 20 March 2024

OCA — Wed, 20 Mar 2024 08:17:35 GMT

←Older revision		Revision as of 08:17, 20 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8fhf is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437==
-		+	<StructureSection load='8fhf' size='340' side='right'caption='[[8fhf]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~: ~~Shang~~, J., ~~Kojetin~~, D.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8fhf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FHF FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of PPARgamma ligand~~-~~binding domain~~ in ~~complex~~ with ~~ZINC5672437~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KNA:NONANOIC+ACID'>KNA</scene>, <scene name='pdbligand=XZK:N-(4-carbamoylphenyl)-2-chloro-5-nitrobenzamide'>XZK</scene></td></tr>
-	[[Category: ~~Shang, J~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fhf OCA], [https://pdbe.org/8fhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fhf RCSB], [https://www.ebi.ac.uk/pdbsum/8fhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fhf ProSAT]</span></td></tr>
-	[[Category: Kojetin~~, D.~~J]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Kojetin DJ]]
		+	[[Category: Shang J]]

OCA at 05:04, 18 January 2023

OCA — Wed, 18 Jan 2023 05:04:56 GMT

←Older revision		Revision as of 05:04, 18 January 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fhf is ON HOLD	+	The entry 8fhf is ON HOLD until Paper Publication

	Authors: Shang, J., Kojetin, D.J.		Authors: Shang, J., Kojetin, D.J.

OCA: Protected "8fhf" [edit=sysop:move=sysop]

OCA — Wed, 21 Dec 2022 06:48:27 GMT

Protected "8fhf" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:48, 21 December 2022

OCA: New page: '''Unreleased structure''' The entry 8fhf is ON HOLD Authors: Shang, J., Kojetin, D.J. Description: Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437 [[C...

OCA — Wed, 21 Dec 2022 06:48:25 GMT

New page: '''Unreleased structure''' The entry 8fhf is ON HOLD Authors: Shang, J., Kojetin, D.J. Description: Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437 [[C...

New page

'''Unreleased structure'''

The entry 8fhf is ON HOLD

Authors: Shang, J., Kojetin, D.J.

Description: Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437
[[Category: Unreleased Structures]]
[[Category: Shang, J]]
[[Category: Kojetin, D.J]]

8fhf - Revision history

OCA at 08:17, 20 March 2024

OCA at 05:04, 18 January 2023

OCA: Protected "8fhf" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8fhf is ON HOLD Authors: Shang, J., Kojetin, D.J. Description: Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437 [[C...