8fik - Revision history

OCA at 06:21, 6 September 2023

OCA — Wed, 06 Sep 2023 06:21:34 GMT

←Older revision		Revision as of 06:21, 6 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8fik ~~is ON HOLD until Paper Publication~~	+	==APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate==
-		+	<StructureSection load='8fik' size='340' side='right'caption='[[8fik]], [[Resolution\|resolution]] 1.91Å' scene=''>
-	~~Authors~~: ~~Harjes~~, S., ~~Jameson~~, G.B., ~~Harjes~~, E., ~~Filichev~~, V.V., ~~Kurup, H~~.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8fik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FIK FirstGlance]. <br>
-	~~Description~~: ~~APOBEC3A E72A inactive mutant in complex~~ with ~~ATTC~~-~~hairpin~~ DNA ~~substrate~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.912Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Kurup, H.M~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fik OCA], [https://pdbe.org/8fik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fik RCSB], [https://www.ebi.ac.uk/pdbsum/8fik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fik ProSAT]</span></td></tr>
-	[[Category: ~~Jameson, G.B~~]]	+	</table>
-	[[Category: Harjes, E]]	+	== Function ==
-	[[Category: ~~Filichev, V.V~~]]	+	[https://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref>
-	[[Category: ~~Harjes, S~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Filichev VV]]
		+	[[Category: Harjes E]]
		+	[[Category: Harjes S]]
		+	[[Category: Jameson GB]]
		+	[[Category: Kurup HM]]

OCA at 04:42, 29 March 2023

OCA — Wed, 29 Mar 2023 04:42:33 GMT

←Older revision		Revision as of 04:42, 29 March 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fik is ON HOLD	+	The entry 8fik is ON HOLD until Paper Publication

	Authors: Harjes, S., Jameson, G.B., Harjes, E., Filichev, V.V., Kurup, H.M.		Authors: Harjes, S., Jameson, G.B., Harjes, E., Filichev, V.V., Kurup, H.M.
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	Description: APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate		Description: APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Filichev, V.V]]
	[[Category: Kurup, H.M]]		[[Category: Kurup, H.M]]
	[[Category: Jameson, G.B]]		[[Category: Jameson, G.B]]
	[[Category: Harjes, E]]		[[Category: Harjes, E]]
		+	[[Category: Filichev, V.V]]
	[[Category: Harjes, S]]		[[Category: Harjes, S]]

OCA: Protected "8fik" [edit=sysop:move=sysop]

OCA — Wed, 28 Dec 2022 05:54:35 GMT

Protected "8fik" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:54, 28 December 2022

OCA: New page: '''Unreleased structure''' The entry 8fik is ON HOLD Authors: Harjes, S., Jameson, G.B., Harjes, E., Filichev, V.V., Kurup, H.M. Description: APOBEC3A E72A inactive mutant in complex w...

OCA — Wed, 28 Dec 2022 05:54:32 GMT

New page: '''Unreleased structure''' The entry 8fik is ON HOLD Authors: Harjes, S., Jameson, G.B., Harjes, E., Filichev, V.V., Kurup, H.M. Description: APOBEC3A E72A inactive mutant in complex w...

New page

'''Unreleased structure'''

The entry 8fik is ON HOLD

Authors: Harjes, S., Jameson, G.B., Harjes, E., Filichev, V.V., Kurup, H.M.

Description: APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate
[[Category: Unreleased Structures]]
[[Category: Filichev, V.V]]
[[Category: Kurup, H.M]]
[[Category: Jameson, G.B]]
[[Category: Harjes, E]]
[[Category: Harjes, S]]