OCA at 07:04, 25 October 2023

OCA — Wed, 25 Oct 2023 07:04:33 GMT

←Older revision		Revision as of 07:04, 25 October 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 8fk2 is ~~ON HOLD until 2024~~-12-20	+	==The N-terminal VicR from Streptococcus mutans==
		+	<StructureSection load='8fk2' size='340' side='right'caption='[[8fk2]], [[Resolution\|resolution]] 2.29Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8fk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans_UA159 Streptococcus mutans UA159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FK2 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.29Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fk2 OCA], [https://pdbe.org/8fk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fk2 RCSB], [https://www.ebi.ac.uk/pdbsum/8fk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fk2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/I6L8Z5_STRMU I6L8Z5_STRMU]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibiotic tolerance within a biofilm community presents a serious public health challenge. Here, we report the identification of a 2-aminoimidazole derivative that inhibits biofilm formation by two pathogenic Gram-positive bacteria, Streptococcus mutans and Staphylococcus aureus. In S. mutans, the compound binds to VicR, a key response regulator, at the N-terminal receiver domain, and concurrently inhibits expression of vicR and VicR-regulated genes, including the genes that encode the key biofilm matrix producing enzymes, Gtfs. The compound inhibits S. aureus biofilm formation via binding to a Staphylococcal VicR homolog. In addition, the inhibitor effectively attenuates S. mutans virulence in a rat model of dental caries. As the compound targets bacterial biofilms and virulence through a conserved transcriptional factor, it represents a promising new class of anti-infective agents that can be explored to prevent or treat a host of bacterial infections. IMPORTANCE Antibiotic resistance is a major public health issue due to the growing lack of effective anti-infective therapeutics. New alternatives to treat and prevent biofilm-driven microbial infections, which exhibit high tolerance to clinically available antibiotics, are urgently needed. We report the identification of a small molecule that inhibits biofilm formation by two important pathogenic Gram-positive bacteria, Streptococcus mutans and Staphylococcus aureus. The small molecule selectively targets a transcriptional regulator leading to attenuation of a biofilm regulatory cascade and concurrent reduction of bacterial virulence in vivo. As the regulator is highly conserved, the finding has broad implication for the development of antivirulence therapeutics that selectively target biofilms.

-	~~Authors:~~ Zhang, H., Wu, H.	+	Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator.,Liu C, Zhang H, Peng X, Blackledge MS, Furlani RE, Li H, Su Z, Melander RJ, Melander C, Michalek S, Wu H mBio. 2023 Jun 27;14(3):e0013723. doi: 10.1128/mbio.00137-23. Epub 2023 Apr 19. PMID:37074183<ref>PMID:37074183</ref>

-	~~Description: The N~~-~~terminal VicR from Streptococcus mutans~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Zhang, H~~]]	+	<div class="pdbe-citations 8fk2" style="background-color:#fffaf0;"></div>
-	[[Category: Wu, H]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Streptococcus mutans UA159]]
		+	[[Category: Wu H]]
		+	[[Category: Zhang H]]

OCA at 05:08, 8 February 2023

OCA — Wed, 08 Feb 2023 05:08:23 GMT

←Older revision		Revision as of 05:08, 8 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fk2 is ON HOLD	+	The entry 8fk2 is ON HOLD until 2024-12-20

	Authors: Zhang, H., Wu, H.		Authors: Zhang, H., Wu, H.

OCA at 05:51, 11 January 2023

OCA — Wed, 11 Jan 2023 05:51:15 GMT

←Older revision		Revision as of 05:51, 11 January 2023
Line 3:		Line 3:
	The entry 8fk2 is ON HOLD		The entry 8fk2 is ON HOLD

-	Authors: ~~Hua~~, Z., ~~Hui~~, W.	+	Authors: Zhang, H., Wu, H.

	Description: The N-terminal VicR from Streptococcus mutans		Description: The N-terminal VicR from Streptococcus mutans
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Hui~~, W]]	+	[[Category: Zhang, H]]
-	[[Category: ~~Hua~~, Z]]	+	[[Category: Wu, H]]

OCA: Protected "8fk2" [edit=sysop:move=sysop]

OCA — Wed, 28 Dec 2022 06:04:37 GMT

Protected "8fk2" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:04, 28 December 2022

OCA: New page: '''Unreleased structure''' The entry 8fk2 is ON HOLD Authors: Hua, Z., Hui, W. Description: The N-terminal VicR from Streptococcus mutans Category: Unreleased Structures [[Category...

OCA — Wed, 28 Dec 2022 06:04:34 GMT

New page: '''Unreleased structure''' The entry 8fk2 is ON HOLD Authors: Hua, Z., Hui, W. Description: The N-terminal VicR from Streptococcus mutans Category: Unreleased Structures [[Category...

New page

'''Unreleased structure'''

The entry 8fk2 is ON HOLD

Authors: Hua, Z., Hui, W.

Description: The N-terminal VicR from Streptococcus mutans
[[Category: Unreleased Structures]]
[[Category: Hui, W]]
[[Category: Hua, Z]]

8fk2 - Revision history

OCA at 07:04, 25 October 2023

OCA at 05:08, 8 February 2023

OCA at 05:51, 11 January 2023

OCA: Protected "8fk2" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8fk2 is ON HOLD Authors: Hua, Z., Hui, W. Description: The N-terminal VicR from Streptococcus mutans Category: Unreleased Structures [[Category...