OCA at 17:06, 26 April 2023

OCA — Wed, 26 Apr 2023 17:06:51 GMT

←Older revision		Revision as of 17:06, 26 April 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~8fls~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Human PTH1R in complex with Abaloparatide and Gs==
-		+	<StructureSection load='8fls' size='340' side='right'caption='[[8fls]], [[Resolution\|resolution]] 3.09Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8fls]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FLS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fls OCA], [https://pdbe.org/8fls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fls RCSB], [https://www.ebi.ac.uk/pdbsum/8fls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fls ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Lama glama]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Belousoff MJ]]
		+	[[Category: Cary BP]]
		+	[[Category: Piper SJ]]
		+	[[Category: Sexton PM]]
		+	[[Category: Wootten D]]

OCA at 09:21, 1 February 2023

OCA — Wed, 01 Feb 2023 09:21:51 GMT

←Older revision		Revision as of 09:21, 1 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fls is ON HOLD	+	The entry 8fls is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8fls" [edit=sysop:move=sysop]

OCA — Wed, 28 Dec 2022 06:12:50 GMT

Protected "8fls" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:12, 28 December 2022

OCA: New page: '''Unreleased structure''' The entry 8fls is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Dec 2022 06:12:49 GMT

New page: '''Unreleased structure''' The entry 8fls is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8fls is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8fls - Revision history

OCA at 17:06, 26 April 2023

OCA at 09:21, 1 February 2023

OCA: Protected "8fls" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8fls is ON HOLD Authors: Description: Category: Unreleased Structures