8fp5 - Revision history

OCA at 10:33, 25 October 2023

OCA — Wed, 25 Oct 2023 10:33:28 GMT

←Older revision		Revision as of 10:33, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8fp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FP5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8fp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FP5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fp5 OCA], [https://pdbe.org/8fp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fp5 RCSB], [https://www.ebi.ac.uk/pdbsum/8fp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fp5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fp5 OCA], [https://pdbe.org/8fp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fp5 RCSB], [https://www.ebi.ac.uk/pdbsum/8fp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fp5 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 05:43, 31 May 2023

OCA — Wed, 31 May 2023 05:43:33 GMT

←Older revision		Revision as of 05:43, 31 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8fp5 is ~~ON HOLD until Paper Publication~~	+	==CDK2 liganded with ATP and Mg2+==
-		+	<StructureSection load='8fp5' size='340' side='right'caption='[[8fp5]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~Authors~~: ~~Schonbrunn~~, E., ~~Sun~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8fp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FP5 FirstGlance]. <br>
-	~~Description~~: CDK2 ~~liganded~~ with ~~ATP~~ and ~~Mg2+~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fp5 OCA], [https://pdbe.org/8fp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fp5 RCSB], [https://www.ebi.ac.uk/pdbsum/8fp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fp5 ProSAT]</span></td></tr>
-	[[Category: Schonbrunn, E]]	+	</table>
-	[[Category: Sun, L]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Schonbrunn E]]
		+	[[Category: Sun L]]

OCA at 05:07, 18 January 2023

OCA — Wed, 18 Jan 2023 05:07:58 GMT

←Older revision		Revision as of 05:07, 18 January 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fp5 is ON HOLD	+	The entry 8fp5 is ON HOLD until Paper Publication

	Authors: Schonbrunn, E., Sun, L.		Authors: Schonbrunn, E., Sun, L.

OCA: Protected "8fp5" [edit=sysop:move=sysop]

OCA — Wed, 11 Jan 2023 06:00:05 GMT

Protected "8fp5" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 11 January 2023

OCA: New page: '''Unreleased structure''' The entry 8fp5 is ON HOLD Authors: Schonbrunn, E., Sun, L. Description: CDK2 liganded with ATP and Mg2+ Category: Unreleased Structures [[Category: Schon...

OCA — Wed, 11 Jan 2023 06:00:02 GMT

New page: '''Unreleased structure''' The entry 8fp5 is ON HOLD Authors: Schonbrunn, E., Sun, L. Description: CDK2 liganded with ATP and Mg2+ Category: Unreleased Structures [[Category: Schon...

New page

'''Unreleased structure'''

The entry 8fp5 is ON HOLD

Authors: Schonbrunn, E., Sun, L.

Description: CDK2 liganded with ATP and Mg2+
[[Category: Unreleased Structures]]
[[Category: Schonbrunn, E]]
[[Category: Sun, L]]