OCA at 09:35, 1 March 2024

OCA — Fri, 01 Mar 2024 09:35:19 GMT

←Older revision		Revision as of 09:35, 1 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8fq3 is ~~ON HOLD until Paper Publication~~	+	==LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K)==
-		+	<StructureSection load='8fq3' size='340' side='right'caption='[[8fq3]], [[Resolution\|resolution]] 3.17Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8fq3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FQ3 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.17Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYZ:CYCLOTHIAZIDE'>CYZ</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fq3 OCA], [https://pdbe.org/8fq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fq3 RCSB], [https://www.ebi.ac.uk/pdbsum/8fq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fq3 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Nakagawa T]]

OCA at 04:57, 25 January 2023

OCA — Wed, 25 Jan 2023 04:57:32 GMT

←Older revision		Revision as of 04:57, 25 January 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fq3 is ON HOLD	+	The entry 8fq3 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8fq3" [edit=sysop:move=sysop]

OCA — Wed, 11 Jan 2023 06:02:44 GMT

Protected "8fq3" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:02, 11 January 2023

OCA: New page: '''Unreleased structure''' The entry 8fq3 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Jan 2023 06:02:41 GMT

New page: '''Unreleased structure''' The entry 8fq3 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8fq3 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8fq3 - Revision history

OCA at 09:35, 1 March 2024

OCA at 04:57, 25 January 2023

OCA: Protected "8fq3" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8fq3 is ON HOLD Authors: Description: Category: Unreleased Structures