8fub - Revision history

OCA at 07:46, 23 August 2023

OCA — Wed, 23 Aug 2023 07:46:59 GMT

←Older revision		Revision as of 07:46, 23 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8fub]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hendra_virus_horse/Australia/Hendra/1994 Hendra virus horse/Australia/Hendra/1994] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FUB FirstGlance]. <br>		<table><tr><td colspan='2'>[[8fub]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hendra_virus_horse/Australia/Hendra/1994 Hendra virus horse/Australia/Hendra/1994] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FUB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fub OCA], [https://pdbe.org/8fub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fub RCSB], [https://www.ebi.ac.uk/pdbsum/8fub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fub ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fub OCA], [https://pdbe.org/8fub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fub RCSB], [https://www.ebi.ac.uk/pdbsum/8fub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fub ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/IMA3_HUMAN IMA3_HUMAN] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.		[https://www.uniprot.org/uniprot/IMA3_HUMAN IMA3_HUMAN] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
		+
		+	==See Also==
		+	*[[Importin 3D structures\|Importin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:29, 15 February 2023

OCA — Wed, 15 Feb 2023 10:29:40 GMT

←Older revision		Revision as of 10:29, 15 February 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8fub ~~is ON HOLD~~	+	==Crystal structure of human Importin alpha 3 in complex with Hendra virus matrix protein NLS1==
-		+	<StructureSection load='8fub' size='340' side='right'caption='[[8fub]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~Authors~~: ~~Donnelly~~, C.M., ~~Basler~~, C.F., ~~Scott, C~~., ~~Forwood, J~~.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8fub]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hendra_virus_horse/Australia/Hendra/1994 Hendra virus horse/Australia/Hendra/1994] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FUB FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of human Importin alpha 3~~ in complex ~~with~~ Hendra virus ~~matrix protein NLS1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fub OCA], [https://pdbe.org/8fub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fub RCSB], [https://www.ebi.ac.uk/pdbsum/8fub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fub ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Forwood, J.K~~]]	+	== Function ==
-	[[Category: ~~Scott, C~~]]	+	[https://www.uniprot.org/uniprot/IMA3_HUMAN IMA3_HUMAN] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
-	[[Category: ~~Basler, C.F~~]]	+	__TOC__
-	[[Category: ~~Donnelly,~~ C.M]]	+	</StructureSection>
		+	[[Category: Hendra virus horse/Australia/Hendra/1994]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Basler CF]]
		+	[[Category: Donnelly CM]]
		+	[[Category: Forwood JK]]
		+	[[Category: Scott C]]

OCA: Protected "8fub" [edit=sysop:move=sysop]

OCA — Wed, 25 Jan 2023 04:59:56 GMT

Protected "8fub" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:59, 25 January 2023

OCA: New page: '''Unreleased structure''' The entry 8fub is ON HOLD Authors: Donnelly, C.M., Basler, C.F., Scott, C., Forwood, J.K. Description: Crystal structure of human Importin alpha 3 in complex...

OCA — Wed, 25 Jan 2023 04:59:55 GMT

New page: '''Unreleased structure''' The entry 8fub is ON HOLD Authors: Donnelly, C.M., Basler, C.F., Scott, C., Forwood, J.K. Description: Crystal structure of human Importin alpha 3 in complex...

New page

'''Unreleased structure'''

The entry 8fub is ON HOLD

Authors: Donnelly, C.M., Basler, C.F., Scott, C., Forwood, J.K.

Description: Crystal structure of human Importin alpha 3 in complex with Hendra virus matrix protein NLS1
[[Category: Unreleased Structures]]
[[Category: Forwood, J.K]]
[[Category: Scott, C]]
[[Category: Basler, C.F]]
[[Category: Donnelly, C.M]]