8g30 - Revision history

OCA at 21:26, 28 June 2023

OCA — Wed, 28 Jun 2023 21:26:38 GMT

←Older revision		Revision as of 21:26, 28 June 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8g30]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G30 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8g30]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G30 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g30 OCA], [https://pdbe.org/8g30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g30 RCSB], [https://www.ebi.ac.uk/pdbsum/8g30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g30 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g30 OCA], [https://pdbe.org/8g30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g30 RCSB], [https://www.ebi.ac.uk/pdbsum/8g30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g30 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 05:44, 31 May 2023

OCA — Wed, 31 May 2023 05:44:01 GMT

←Older revision		Revision as of 05:44, 31 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8g30 is ~~ON HOLD until Paper Publication~~	+	==N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules==
-		+	<StructureSection load='8g30' size='340' side='right'caption='[[8g30]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~Authors~~: ~~Dang~~, H.V., ~~Snell~~, G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8g30]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G30 FirstGlance]. <br>
-	~~Description~~: ~~N2 neuraminidase of A~~/~~Tanzania~~/~~205~~/~~2010 H3N2~~ in ~~complex~~ with ~~4 FNI19 Fab molecules~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g30 OCA], [https://pdbe.org/8g30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g30 RCSB], [https://www.ebi.ac.uk/pdbsum/8g30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g30 ProSAT]</span></td></tr>
-	[[Category: Dang~~, H.V~~]]	+	</table>
-	[[Category: Snell, G]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/V9SU56_9INFA V9SU56_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Influenza A virus]]
		+	[[Category: Large Structures]]
		+	[[Category: Dang HV]]
		+	[[Category: Snell G]]

OCA at 07:41, 15 March 2023

OCA — Wed, 15 Mar 2023 07:41:21 GMT

←Older revision		Revision as of 07:41, 15 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8g30 is ON HOLD	+	The entry 8g30 is ON HOLD until Paper Publication

	Authors: Dang, H.V., Snell, G.		Authors: Dang, H.V., Snell, G.

OCA: Protected "8g30" [edit=sysop:move=sysop]

OCA — Wed, 15 Feb 2023 08:47:47 GMT

Protected "8g30" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:47, 15 February 2023

OCA: New page: '''Unreleased structure''' The entry 8g30 is ON HOLD Authors: Dang, H.V., Snell, G. Description: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules [[Ca...

OCA — Wed, 15 Feb 2023 08:47:46 GMT

New page: '''Unreleased structure''' The entry 8g30 is ON HOLD Authors: Dang, H.V., Snell, G. Description: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules [[Ca...

New page

'''Unreleased structure'''

The entry 8g30 is ON HOLD

Authors: Dang, H.V., Snell, G.

Description: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules
[[Category: Unreleased Structures]]
[[Category: Dang, H.V]]
[[Category: Snell, G]]