8g54 - Revision history

OCA at 07:47, 23 August 2023

OCA — Wed, 23 Aug 2023 07:47:05 GMT

←Older revision		Revision as of 07:47, 23 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8g54]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G54 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8g54]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G54 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g54 OCA], [https://pdbe.org/8g54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g54 RCSB], [https://www.ebi.ac.uk/pdbsum/8g54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g54 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g54 OCA], [https://pdbe.org/8g54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g54 RCSB], [https://www.ebi.ac.uk/pdbsum/8g54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g54 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.<ref>PMID:21985311</ref>		[https://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.<ref>PMID:21985311</ref>
		+
		+	==See Also==
		+	*[[Microtubule-associated protein 3D structures\|Microtubule-associated protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:40, 7 June 2023

OCA — Wed, 07 Jun 2023 05:40:50 GMT

←Older revision		Revision as of 05:40, 7 June 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8g54 ~~is ON HOLD until Paper Publication~~	+	==Temperature-dependent structures of tau aggregates==
-		+	<StructureSection load='8g54' size='340' side='right'caption='[[8g54]]' scene=''>
-	~~Authors~~: ~~El Mammeri~~, N., ~~Duan~~, P., ~~Dregni~~, A.J., ~~Hong~~, M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8g54]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G54 FirstGlance]. <br>
-	~~Description~~: ~~Temperature-dependent structures~~ of tau ~~aggregates~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g54 OCA], [https://pdbe.org/8g54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g54 RCSB], [https://www.ebi.ac.uk/pdbsum/8g54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g54 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Hong, M~~]]	+	== Disease ==
-	[[Category: Duan, P]]	+	[https://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN] Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P-TAU). O-GlcNAcylation is greatly reduced in Alzheimer disease brain cerebral cortex leading to an increase in TAU/MAPT phosphorylations.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> Defects in MAPT are a cause of frontotemporal dementia (FTD) [MIM:[https://omim.org/entry/600274 600274]; also called frontotemporal dementia (FTD), pallido-ponto-nigral degeneration (PPND) or historically termed Pick complex. This form of frontotemporal dementia is characterized by presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> <ref>PMID:9629852</ref> <ref>PMID:9736786</ref> <ref>PMID:9641683</ref> <ref>PMID:9789048</ref> <ref>PMID:9973279</ref> <ref>PMID:10553987</ref> <ref>PMID:10214944</ref> <ref>PMID:10374757</ref> <ref>PMID:10489057</ref> <ref>PMID:10208578</ref> <ref>PMID:11117541</ref> <ref>PMID:10802785</ref> <ref>PMID:11071507</ref> <ref>PMID:11585254</ref> <ref>PMID:11278002</ref> <ref>PMID:12473774</ref> <ref>PMID:11921059</ref> <ref>PMID:11906000</ref> <ref>PMID:11889249</ref> <ref>PMID:12509859</ref> <ref>PMID:16240366</ref> <ref>PMID:15883319</ref> Defects in MAPT are a cause of Pick disease of the brain (PIDB) [MIM:[https://omim.org/entry/172700 172700]. It is a rare form of dementia pathologically defined by severe atrophy, neuronal loss and gliosis. It is characterized by the occurrence of tau-positive inclusions, swollen neurons (Pick cells) and argentophilic neuronal inclusions known as Pick bodies that disproportionally affect the frontal and temporal cortical regions. Clinical features include aphasia, apraxia, confusion, anomia, memory loss and personality deterioration.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> <ref>PMID:10604746</ref> <ref>PMID:11117542</ref> <ref>PMID:11089577</ref> <ref>PMID:11601501</ref> <ref>PMID:11891833</ref> Note=Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> Defects in MAPT are a cause of progressive supranuclear palsy type 1 (PSNP1) [MIM:[https://omim.org/entry/601104 601104]; also abbreviated as PSP and also known as Steele-Richardson-Olszewski syndrome. PSNP1 is characterized by akinetic-rigid syndrome, supranuclear gaze palsy, pyramidal tract dysfunction, pseudobulbar signs and cognitive capacities deterioration. Neurofibrillary tangles and gliosis but no amyloid plaques are found in diseased brains. Most cases appear to be sporadic, with a significant association with a common haplotype including the MAPT gene and the flanking regions. Familial cases show an autosomal dominant pattern of transmission with incomplete penetrance; genetic analysis of a few cases showed the occurrence of tau mutations, including a deletion of Asn-613.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> <ref>PMID:10534245</ref> <ref>PMID:11220749</ref> <ref>PMID:12325083</ref> <ref>PMID:14991829</ref> <ref>PMID:14991828</ref> <ref>PMID:16157753</ref> Defects in MAPT are a cause of Parkinson-dementia syndrome (PARDE) [MIM:[https://omim.org/entry/260540 260540]. A syndrome characterized by parkinsonism tremor, rigidity, dementia, ophthalmoparesis and pyramidal signs. Neurofibrillary degeneration occurs in the hippocampus, basal ganglia and brainstem nuclei.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref>
-	[[Category: El Mammeri, N]]	+	== Function ==
-	[[Category: ~~Dregni, A.J~~]]	+	[https://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.<ref>PMID:21985311</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Dregni AJ]]
		+	[[Category: Duan P]]
		+	[[Category: El Mammeri N]]
		+	[[Category: Hong M]]

OCA at 04:28, 2 March 2023

OCA — Thu, 02 Mar 2023 04:28:03 GMT

←Older revision		Revision as of 04:28, 2 March 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8g54 is ON HOLD	+	The entry 8g54 is ON HOLD until Paper Publication

	Authors: El Mammeri, N., Duan, P., Dregni, A.J., Hong, M.		Authors: El Mammeri, N., Duan, P., Dregni, A.J., Hong, M.

-	Description: ~~Influence~~ of ~~Fibril Growth Rates on the Structure of Tau Aggregates~~	+	Description: Temperature-dependent structures of tau aggregates
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Dregni, A.J]]
	[[Category: Hong, M]]		[[Category: Hong, M]]
	[[Category: Duan, P]]		[[Category: Duan, P]]
	[[Category: El Mammeri, N]]		[[Category: El Mammeri, N]]
		+	[[Category: Dregni, A.J]]

OCA: Protected "8g54" [edit=sysop:move=sysop]

OCA — Wed, 22 Feb 2023 10:19:33 GMT

Protected "8g54" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:19, 22 February 2023

OCA: New page: '''Unreleased structure''' The entry 8g54 is ON HOLD Authors: El Mammeri, N., Duan, P., Dregni, A.J., Hong, M. Description: Influence of Fibril Growth Rates on the Structure of Tau Agg...

OCA — Wed, 22 Feb 2023 10:19:31 GMT

New page: '''Unreleased structure''' The entry 8g54 is ON HOLD Authors: El Mammeri, N., Duan, P., Dregni, A.J., Hong, M. Description: Influence of Fibril Growth Rates on the Structure of Tau Agg...

New page

'''Unreleased structure'''

The entry 8g54 is ON HOLD

Authors: El Mammeri, N., Duan, P., Dregni, A.J., Hong, M.

Description: Influence of Fibril Growth Rates on the Structure of Tau Aggregates
[[Category: Unreleased Structures]]
[[Category: Dregni, A.J]]
[[Category: Hong, M]]
[[Category: Duan, P]]
[[Category: El Mammeri, N]]