8g5e - Revision history

OCA at 10:49, 22 May 2024

OCA — Wed, 22 May 2024 10:49:30 GMT

OCA: Protected "8g5e" [edit=sysop:move=sysop]

OCA — Wed, 22 Feb 2023 12:47:27 GMT

Protected "8g5e" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:47, 22 February 2023

OCA: New page: ==Crystal Structure of SETDB1 Tudor domain in complex with UNC6535== == Structural highlights ==
<table><tr><td colspan='2'>[[8g5e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G5E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=YOH:N~4~-[6-(dimethylamino)hexyl]-N~2~-[5-(dimethylamino)pentyl]-6,7-dimethoxyquinazoline-2,4-diamine'>YOH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g5e OCA], [https://pdbe.org/8g5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g5e RCSB], [https://www.ebi.ac.uk/pdbsum/8g5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g5e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Beldar S]]
[[Category: Brown PJ]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: Halabelian L]]