OCA at 08:54, 21 February 2024

OCA — Wed, 21 Feb 2024 08:54:55 GMT

←Older revision		Revision as of 08:54, 21 February 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8g76 is ~~ON HOLD until Paper Publication~~	+	==SARS-CoV-2 spike/Nb5 complex==
-		+	<StructureSection load='8g76' size='340' side='right'caption='[[8g76]], [[Resolution\|resolution]] 3.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8g76]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G76 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.8Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g76 OCA], [https://pdbe.org/8g76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g76 RCSB], [https://www.ebi.ac.uk/pdbsum/8g76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g76 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Vicugna pacos]]
		+	[[Category: Bu F]]
		+	[[Category: Li F]]
		+	[[Category: Liu B]]
		+	[[Category: Ye G]]

OCA at 05:39, 22 March 2023

OCA — Wed, 22 Mar 2023 05:39:43 GMT

←Older revision		Revision as of 05:39, 22 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8g76 is ON HOLD	+	The entry 8g76 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8g76" [edit=sysop:move=sysop]

OCA — Wed, 22 Feb 2023 10:25:56 GMT

Protected "8g76" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:25, 22 February 2023

OCA: New page: '''Unreleased structure''' The entry 8g76 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Feb 2023 10:25:55 GMT

New page: '''Unreleased structure''' The entry 8g76 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8g76 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8g76 - Revision history

OCA at 08:54, 21 February 2024

OCA at 05:39, 22 March 2023

OCA: Protected "8g76" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8g76 is ON HOLD Authors: Description: Category: Unreleased Structures