OCA at 08:55, 21 February 2024

OCA — Wed, 21 Feb 2024 08:55:03 GMT

←Older revision		Revision as of 08:55, 21 February 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8g8h is ~~ON HOLD~~ until ~~Paper Publication~~	+	==Crystal structure of human DNA polymerase eta incorporating ITP across dC==
-		+	<StructureSection load='8g8h' size='340' side='right'caption='[[8g8h]], [[Resolution\|resolution]] 1.64Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8g8h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G8H FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.64Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CZU:[[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+phosphono+hydrogen+phosphate'>CZU</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g8h OCA], [https://pdbe.org/8g8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g8h RCSB], [https://www.ebi.ac.uk/pdbsum/8g8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g8h ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/POLH_HUMAN POLH_HUMAN] Defects in POLH are the cause of xeroderma pigmentosum variant type (XPV) [MIM:[https://omim.org/entry/278750 278750]; also designated as XP-V. Xeroderma pigmentosum (XP) is an autosomal recessive disease due to deficient nucleotide excision repair. It is characterized by hypersensitivity of the skin to sunlight, followed by high incidence of skin cancer and frequent neurologic abnormalities. XPV shows normal nucleotide excision repair, but an exaggerated delay in recovery of replicative DNA synthesis. Most XPV patients do not develop clinical symptoms and skin neoplasias until a later age. Clinical manifestations are limited to photo-induced deterioration of the skin and eyes.<ref>PMID:10385124</ref> <ref>PMID:10398605</ref> <ref>PMID:11032022</ref> <ref>PMID:11121129</ref> <ref>PMID:11773631</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/POLH_HUMAN POLH_HUMAN] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.<ref>PMID:10385124</ref> <ref>PMID:11743006</ref> <ref>PMID:11376341</ref> <ref>PMID:14630940</ref> <ref>PMID:14734526</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Jung H]]

OCA: Protected "8g8h" [edit=sysop:move=sysop]

OCA — Thu, 02 Mar 2023 04:30:36 GMT

Protected "8g8h" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:30, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8g8h is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Thu, 02 Mar 2023 04:30:35 GMT

New page: '''Unreleased structure''' The entry 8g8h is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8g8h is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

8g8h - Revision history

OCA at 08:55, 21 February 2024

OCA: Protected "8g8h" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8g8h is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures