OCA at 08:55, 21 February 2024

OCA — Wed, 21 Feb 2024 08:55:08 GMT

←Older revision		Revision as of 08:55, 21 February 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8g8s is ~~ON HOLD until Paper Publication~~	+	==bipartite p52 NLS in complex with Importin alpha 2==
-		+	<StructureSection load='8g8s' size='340' side='right'caption='[[8g8s]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~: ~~Tsimbslyuk~~, S., ~~Stewart~~, M., ~~Forwood~~, J.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8g8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G8S FirstGlance]. <br>
-	~~Description~~: bipartite ~~p52~~ NLS in complex ~~with Importin~~ alpha 2	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g8s OCA], [https://pdbe.org/8g8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g8s RCSB], [https://www.ebi.ac.uk/pdbsum/8g8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g8s ProSAT]</span></td></tr>
-	[[Category: Forwood~~, J.K~~]]	+	</table>
-	[[Category: Stewart, M]]	+	== Function ==
-	[[Category: Tsimbslyuk, S]]	+	[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Forwood JK]]
		+	[[Category: Stewart M]]
		+	[[Category: Tsimbslyuk S]]

OCA at 04:54, 7 April 2023

OCA — Fri, 07 Apr 2023 04:54:45 GMT

←Older revision		Revision as of 04:54, 7 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8g8s is ON HOLD	+	The entry 8g8s is ON HOLD until Paper Publication

	Authors: Tsimbslyuk, S., Stewart, M., Forwood, J.K.		Authors: Tsimbslyuk, S., Stewart, M., Forwood, J.K.

OCA: Protected "8g8s" [edit=sysop:move=sysop]

OCA — Thu, 02 Mar 2023 04:31:06 GMT

Protected "8g8s" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:31, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8g8s is ON HOLD Authors: Tsimbslyuk, S., Stewart, M., Forwood, J.K. Description: bipartite p52 NLS in complex with Importin alpha 2 [[Category: Unr...

OCA — Thu, 02 Mar 2023 04:31:05 GMT

New page: '''Unreleased structure''' The entry 8g8s is ON HOLD Authors: Tsimbslyuk, S., Stewart, M., Forwood, J.K. Description: bipartite p52 NLS in complex with Importin alpha 2 [[Category: Unr...

New page

'''Unreleased structure'''

The entry 8g8s is ON HOLD

Authors: Tsimbslyuk, S., Stewart, M., Forwood, J.K.

Description: bipartite p52 NLS in complex with Importin alpha 2
[[Category: Unreleased Structures]]
[[Category: Forwood, J.K]]
[[Category: Stewart, M]]
[[Category: Tsimbslyuk, S]]

8g8s - Revision history

OCA at 08:55, 21 February 2024

OCA at 04:54, 7 April 2023

OCA: Protected "8g8s" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8g8s is ON HOLD Authors: Tsimbslyuk, S., Stewart, M., Forwood, J.K. Description: bipartite p52 NLS in complex with Importin alpha 2 [[Category: Unr...