OCA at 05:41, 7 June 2023

OCA — Wed, 07 Jun 2023 05:41:07 GMT

←Older revision		Revision as of 05:41, 7 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8g8w is ~~ON HOLD until Paper~~ Publication	+	==Molecular mechanism of nucleotide inhibition of human uncoupling protein 1==
		+	<StructureSection load='8g8w' size='340' side='right'caption='[[8g8w]], [[Resolution\|resolution]] 3.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8g8w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G8W FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g8w OCA], [https://pdbe.org/8g8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g8w RCSB], [https://www.ebi.ac.uk/pdbsum/8g8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g8w ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UCP1_HUMAN UCP1_HUMAN] Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).[UniProtKB:P12242]<ref>PMID:24196960</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, UCP1 catalyzes the leak of protons across the mitochondrial inner membrane, short-circuiting the mitochondrion to generate heat, bypassing ATP synthesis. In contrast, purine nucleotides bind and inhibit UCP1, regulating proton leak by a molecular mechanism that is unclear. We present the cryo-electron microscopy structure of the GTP-inhibited state of UCP1, which is consistent with its nonconducting state. The purine nucleotide cross-links the transmembrane helices of UCP1 with an extensive interaction network. Our results provide a structural basis for understanding the specificity and pH dependency of the regulatory mechanism. UCP1 has retained all of the key functional and structural features required for a mitochondrial carrier-like transport mechanism. The analysis shows that inhibitor binding prevents the conformational changes that UCP1 uses to facilitate proton leak.

-	~~Authors~~:	+	Structural basis of purine nucleotide inhibition of human uncoupling protein 1.,Jones SA, Gogoi P, Ruprecht JJ, King MS, Lee Y, Zogg T, Pardon E, Chand D, Steimle S, Copeman DM, Cotrim CA, Steyaert J, Crichton PG, Moiseenkova-Bell V, Kunji ERS Sci Adv. 2023 Jun 2;9(22):eadh4251. doi: 10.1126/sciadv.adh4251. Epub 2023 May , 31. PMID:37256948<ref>PMID:37256948</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8g8w" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli K-12]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Chand D]]
		+	[[Category: Copeman D]]
		+	[[Category: Cotrim CA]]
		+	[[Category: Crichton PG]]
		+	[[Category: Gogoi P]]
		+	[[Category: Jones SA]]
		+	[[Category: King MS]]
		+	[[Category: Kunji ERS]]
		+	[[Category: Lee Y]]
		+	[[Category: Moiseenkova-Bell V]]
		+	[[Category: Pardon E]]
		+	[[Category: Ruprecht JJ]]
		+	[[Category: Steimle S]]
		+	[[Category: Steyaert J]]
		+	[[Category: Zogg T]]

OCA at 04:54, 7 April 2023

OCA — Fri, 07 Apr 2023 04:54:48 GMT

←Older revision		Revision as of 04:54, 7 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8g8w is ON HOLD	+	The entry 8g8w is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8g8w" [edit=sysop:move=sysop]

OCA — Thu, 02 Mar 2023 04:31:15 GMT

Protected "8g8w" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:31, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8g8w is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 02 Mar 2023 04:31:14 GMT

New page: '''Unreleased structure''' The entry 8g8w is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8g8w is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8g8w - Revision history

OCA at 05:41, 7 June 2023

OCA at 04:54, 7 April 2023

OCA: Protected "8g8w" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8g8w is ON HOLD Authors: Description: Category: Unreleased Structures