8g92 - Revision history

OCA at 16:12, 13 December 2023

OCA — Wed, 13 Dec 2023 16:12:53 GMT

←Older revision		Revision as of 16:12, 13 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8g92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G92 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8g92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G92 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YUX:3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine'>YUX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YUX:3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine'>YUX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g92 OCA], [https://pdbe.org/8g92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g92 RCSB], [https://www.ebi.ac.uk/pdbsum/8g92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g92 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g92 OCA], [https://pdbe.org/8g92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g92 RCSB], [https://www.ebi.ac.uk/pdbsum/8g92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g92 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:06, 25 May 2023

OCA — Thu, 25 May 2023 04:06:33 GMT

←Older revision		Revision as of 04:06, 25 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8g92 is ~~ON HOLD until Paper Publication~~	+	==Structure of inhibitor 16d-bound SPNS2==
-		+	<StructureSection load='8g92' size='340' side='right'caption='[[8g92]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8g92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G92 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YUX:3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine'>YUX</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g92 OCA], [https://pdbe.org/8g92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g92 RCSB], [https://www.ebi.ac.uk/pdbsum/8g92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g92 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/SPNS2_HUMAN SPNS2_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPNS2_HUMAN SPNS2_HUMAN] Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking (PubMed:19074308, PubMed:23180825, PubMed:21084291). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system (PubMed:19074308, PubMed:23180825). Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:19074308, PubMed:23180825). Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (By similarity). Also required for the egress of immature B-cells from the bone marrow (By similarity). In contrast, not involved in S1P release from red blood cells (By similarity). Involved in auditory function (PubMed:30973865). S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (By similarity). In addition to export, also able to mediate S1P import (By similarity).[UniProtKB:Q91VM4]<ref>PMID:19074308</ref> <ref>PMID:21084291</ref> <ref>PMID:23180825</ref> <ref>PMID:30973865</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen H]]
		+	[[Category: Li X]]

OCA at 04:45, 29 March 2023

OCA — Wed, 29 Mar 2023 04:45:08 GMT

←Older revision		Revision as of 04:45, 29 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8g92 is ON HOLD	+	The entry 8g92 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8g92" [edit=sysop:move=sysop]

OCA — Thu, 02 Mar 2023 04:31:29 GMT

Protected "8g92" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:31, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8g92 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 02 Mar 2023 04:31:28 GMT

New page: '''Unreleased structure''' The entry 8g92 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8g92 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]