OCA at 09:27, 19 April 2023

OCA — Wed, 19 Apr 2023 09:27:47 GMT

←Older revision		Revision as of 09:27, 19 April 2023
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-	'''Unreleased structure'''

-	~~The entry 8g9x is ON HOLD until Paper Publication~~	+	==Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2)==
-		+	<StructureSection load='8g9x' size='340' side='right'caption='[[8g9x]], [[Resolution\|resolution]] 4.46Å' scene=''>
-	~~Authors: Changela, A., Gorman, J., Kwong, P.D.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8g9x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G9X FirstGlance]. <br>
-	~~Description:~~ Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g9x OCA], [https://pdbe.org/8g9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g9x RCSB], [https://www.ebi.ac.uk/pdbsum/8g9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g9x ProSAT]</span></td></tr>
-	[[Category: ~~Kwong, P.D~~]]	+	</table>
-	[[Category: Changela, A]]	+	== Function ==
-	[[Category: Gorman, J]]	+	[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Changela A]]
		+	[[Category: Gorman J]]
		+	[[Category: Kwong PD]]

OCA at 04:45, 29 March 2023

OCA — Wed, 29 Mar 2023 04:45:26 GMT

←Older revision		Revision as of 04:45, 29 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8g9x is ON HOLD	+	The entry 8g9x is ON HOLD until Paper Publication

	Authors: Changela, A., Gorman, J., Kwong, P.D.		Authors: Changela, A., Gorman, J., Kwong, P.D.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Kwong, P.D]]		[[Category: Kwong, P.D]]
-	[[Category: Gorman, J]]
	[[Category: Changela, A]]		[[Category: Changela, A]]
		+	[[Category: Gorman, J]]

OCA: Protected "8g9x" [edit=sysop:move=sysop]

OCA — Thu, 02 Mar 2023 04:32:46 GMT

Protected "8g9x" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:32, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8g9x is ON HOLD Authors: Changela, A., Gorman, J., Kwong, P.D. Description: Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SO...

OCA — Thu, 02 Mar 2023 04:32:46 GMT

New page: '''Unreleased structure''' The entry 8g9x is ON HOLD Authors: Changela, A., Gorman, J., Kwong, P.D. Description: Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SO...

New page

'''Unreleased structure'''

The entry 8g9x is ON HOLD

Authors: Changela, A., Gorman, J., Kwong, P.D.

Description: Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2)
[[Category: Unreleased Structures]]
[[Category: Kwong, P.D]]
[[Category: Gorman, J]]
[[Category: Changela, A]]

8g9x - Revision history

OCA at 09:27, 19 April 2023

OCA at 04:45, 29 March 2023

OCA: Protected "8g9x" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8g9x is ON HOLD Authors: Changela, A., Gorman, J., Kwong, P.D. Description: Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SO...