OCA at 09:27, 19 April 2023

OCA — Wed, 19 Apr 2023 09:27:52 GMT

←Older revision		Revision as of 09:27, 19 April 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8gas is ~~ON HOLD until Paper Publication~~	+	==vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer==
-		+	<StructureSection load='8gas' size='340' side='right'caption='[[8gas]], [[Resolution\|resolution]] 4.04Å' scene=''>
-	~~Authors~~: ~~Gorman~~, J., ~~Kwong~~, P.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8gas]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GAS FirstGlance]. <br>
-	~~Description~~: ~~vFP48~~.~~02 Fab in complex~~ with ~~BG505 DS~~-~~SOSIP Env trimer~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gas OCA], [https://pdbe.org/8gas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gas RCSB], [https://www.ebi.ac.uk/pdbsum/8gas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gas ProSAT]</span></td></tr>
-	[[Category: ~~Kwong, P.D~~]]	+	</table>
-	[[Category: Gorman, J]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Gorman J]]
		+	[[Category: Kwong PD]]

OCA at 04:45, 29 March 2023

OCA — Wed, 29 Mar 2023 04:45:57 GMT

←Older revision		Revision as of 04:45, 29 March 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gas is ON HOLD	+	The entry 8gas is ON HOLD until Paper Publication

	Authors: Gorman, J., Kwong, P.D.		Authors: Gorman, J., Kwong, P.D.

OCA: Protected "8gas" [edit=sysop:move=sysop]

OCA — Thu, 02 Mar 2023 04:34:24 GMT

Protected "8gas" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:34, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8gas is ON HOLD Authors: Gorman, J., Kwong, P.D. Description: vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer [[Category: Unreleased Structu...

OCA — Thu, 02 Mar 2023 04:34:23 GMT

New page: '''Unreleased structure''' The entry 8gas is ON HOLD Authors: Gorman, J., Kwong, P.D. Description: vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 8gas is ON HOLD

Authors: Gorman, J., Kwong, P.D.

Description: vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer
[[Category: Unreleased Structures]]
[[Category: Kwong, P.D]]
[[Category: Gorman, J]]

8gas - Revision history

OCA at 09:27, 19 April 2023

OCA at 04:45, 29 March 2023

OCA: Protected "8gas" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8gas is ON HOLD Authors: Gorman, J., Kwong, P.D. Description: vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer [[Category: Unreleased Structu...