OCA at 13:14, 13 March 2024

OCA — Wed, 13 Mar 2024 13:14:07 GMT

←Older revision		Revision as of 13:14, 13 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8gb4 is ~~ON HOLD until Paper Publication~~	+	==EGFR(T790M/V948R) kinase in complex with benzimidazole allosteric inhibitor==
-		+	<StructureSection load='8gb4' size='340' side='right'caption='[[8gb4]], [[Resolution\|resolution]] 2.59Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8gb4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GB4 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.59Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=YW5:2-[(R)-(1H-benzimidazol-2-yl)(3-fluorophenyl)methyl]-6-[4-(1-methylpiperidin-4-yl)phenyl]-2,3-dihydro-1H-isoindol-1-one'>YW5</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gb4 OCA], [https://pdbe.org/8gb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gb4 RCSB], [https://www.ebi.ac.uk/pdbsum/8gb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gb4 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN] Defects in EGFR are associated with lung cancer (LNCR) [MIM:[https://omim.org/entry/211980 211980]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN] Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref> Isoform 2 may act as an antagonist of EGF action.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Beyett TS]]
		+	[[Category: Eck MJ]]

OCA at 04:55, 7 April 2023

OCA — Fri, 07 Apr 2023 04:55:14 GMT

←Older revision		Revision as of 04:55, 7 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gb4 is ON HOLD	+	The entry 8gb4 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8gb4" [edit=sysop:move=sysop]

OCA — Wed, 08 Mar 2023 05:45:59 GMT

Protected "8gb4" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:45, 8 March 2023

OCA: New page: '''Unreleased structure''' The entry 8gb4 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Mar 2023 05:45:58 GMT

New page: '''Unreleased structure''' The entry 8gb4 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8gb4 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8gb4 - Revision history

OCA at 13:14, 13 March 2024

OCA at 04:55, 7 April 2023

OCA: Protected "8gb4" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8gb4 is ON HOLD Authors: Description: Category: Unreleased Structures