OCA at 12:03, 6 March 2024

OCA — Wed, 06 Mar 2024 12:03:17 GMT

←Older revision		Revision as of 12:03, 6 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8gcd is ~~ON HOLD~~	+	==Full length Integrin AlphaIIbBeta3 in inactive state==
-		+	<StructureSection load='8gcd' size='340' side='right'caption='[[8gcd]], [[Resolution\|resolution]] 2.97Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8gcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GCD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.97Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gcd OCA], [https://pdbe.org/8gcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gcd RCSB], [https://www.ebi.ac.uk/pdbsum/8gcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gcd ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/ITA2B_HUMAN ITA2B_HUMAN] Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:[https://omim.org/entry/273800 273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.<ref>PMID:8282784</ref> <ref>PMID:7508443</ref> <ref>PMID:7706461</ref> <ref>PMID:8704171</ref> <ref>PMID:9215749</ref> <ref>PMID:9473221</ref> <ref>PMID:9763559</ref> <ref>PMID:9722314</ref> <ref>PMID:9734640</ref> <ref>PMID:9920835</ref> <ref>PMID:10607701</ref> <ref>PMID:11798398</ref> <ref>PMID:12181054</ref> <ref>PMID:12083483</ref> <ref>PMID:12424194</ref> <ref>PMID:12506038</ref> <ref>PMID:15099289</ref> <ref>PMID:15219201</ref> <ref>PMID:17018384</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ITA2B_HUMAN ITA2B_HUMAN] Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Huo T]]
		+	[[Category: Wang Z]]
		+	[[Category: Wu H]]

OCA at 03:47, 9 August 2023

OCA — Wed, 09 Aug 2023 03:47:50 GMT

←Older revision		Revision as of 03:47, 9 August 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gcd is ON HOLD ~~until sometime in the future~~	+	The entry 8gcd is ON HOLD

	Authors:		Authors:

OCA at 07:43, 15 March 2023

OCA — Wed, 15 Mar 2023 07:43:59 GMT

←Older revision		Revision as of 07:43, 15 March 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gcd is ON HOLD	+	The entry 8gcd is ON HOLD until sometime in the future

	Authors:		Authors:

OCA: Protected "8gcd" [edit=sysop:move=sysop]

OCA — Wed, 08 Mar 2023 05:48:26 GMT

Protected "8gcd" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:48, 8 March 2023

OCA: New page: '''Unreleased structure''' The entry 8gcd is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Mar 2023 05:48:25 GMT

New page: '''Unreleased structure''' The entry 8gcd is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8gcd is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8gcd - Revision history

OCA at 12:03, 6 March 2024

OCA at 03:47, 9 August 2023

OCA at 07:43, 15 March 2023

OCA: Protected "8gcd" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8gcd is ON HOLD Authors: Description: Category: Unreleased Structures