8gcy - Revision history

OCA at 07:27, 3 April 2024

OCA — Wed, 03 Apr 2024 07:27:15 GMT

←Older revision		Revision as of 07:27, 3 April 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8gcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GCY FirstGlance]. <br>		<table><tr><td colspan='2'>[[8gcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GCY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=Z3N:2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one'>Z3N</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.81Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=Z3N:2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one'>Z3N</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gcy OCA], [https://pdbe.org/8gcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gcy RCSB], [https://www.ebi.ac.uk/pdbsum/8gcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gcy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gcy OCA], [https://pdbe.org/8gcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gcy RCSB], [https://www.ebi.ac.uk/pdbsum/8gcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gcy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/CBLB_HUMAN CBLB_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.<ref>PMID:10022120</ref> <ref>PMID:10086340</ref> <ref>PMID:11087752</ref> <ref>PMID:11526404</ref>		[https://www.uniprot.org/uniprot/CBLB_HUMAN CBLB_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.<ref>PMID:10022120</ref> <ref>PMID:10086340</ref> <ref>PMID:11087752</ref> <ref>PMID:11526404</ref>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:27, 22 March 2023

OCA — Wed, 22 Mar 2023 07:27:41 GMT

←Older revision		Revision as of 07:27, 22 March 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8gcy ~~is ON HOLD~~	+	==Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor==
-		+	<StructureSection load='8gcy' size='340' side='right'caption='[[8gcy]], [[Resolution\|resolution]] 1.81Å' scene=''>
-	~~Authors~~: ~~Kimani, S~~., ~~Zeng~~, H., ~~Dong~~, A., Li, Y., ~~Santhakumar~~, V., ~~Arrowsmith, C~~.H., ~~Edwards~~, A.M., ~~Halabelian, L~~., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8gcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GCY FirstGlance]. <br>
-	~~Description~~: Co-~~crystal structure of CBL~~-B ~~in complex with N~~-~~Aryl isoindolin~~-1-~~one inhibitor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=Z3N:2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one'>Z3N</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gcy OCA], [https://pdbe.org/8gcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gcy RCSB], [https://www.ebi.ac.uk/pdbsum/8gcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gcy ProSAT]</span></td></tr>
-	[[Category: ~~Edwards, A.M~~]]	+	</table>
-	[[Category: Arrowsmith~~, C.H~~]]	+	== Function ==
-	[[Category: ~~Santhakumar, V~~]]	+	[https://www.uniprot.org/uniprot/CBLB_HUMAN CBLB_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.<ref>PMID:10022120</ref> <ref>PMID:10086340</ref> <ref>PMID:11087752</ref> <ref>PMID:11526404</ref>
-	[[Category: ~~Dong, A~~]]	+	== References ==
-	[[Category: ~~Structural Genomics Consortium (Sgc)~~]]	+	<references/>
-	[[Category: ~~Li, Y~~]]	+	__TOC__
-	[[Category: ~~Halabelian, L~~]]	+	</StructureSection>
-	[[Category: ~~Kimani, S~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Zeng, H]]	+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith CH]]
		+	[[Category: Dong A]]
		+	[[Category: Edwards AM]]
		+	[[Category: Halabelian L]]
		+	[[Category: Kimani S]]
		+	[[Category: Li Y]]
		+	[[Category: Santhakumar V]]
		+	[[Category: Zeng H]]

OCA: Protected "8gcy" [edit=sysop:move=sysop]

OCA — Wed, 15 Mar 2023 07:44:24 GMT

Protected "8gcy" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:44, 15 March 2023

OCA: New page: '''Unreleased structure''' The entry 8gcy is ON HOLD Authors: Kimani, S., Zeng, H., Dong, A., Li, Y., Santhakumar, V., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomi...

OCA — Wed, 15 Mar 2023 07:44:23 GMT

New page: '''Unreleased structure''' The entry 8gcy is ON HOLD Authors: Kimani, S., Zeng, H., Dong, A., Li, Y., Santhakumar, V., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomi...

New page

'''Unreleased structure'''

The entry 8gcy is ON HOLD

Authors: Kimani, S., Zeng, H., Dong, A., Li, Y., Santhakumar, V., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)

Description: Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor
[[Category: Unreleased Structures]]
[[Category: Edwards, A.M]]
[[Category: Arrowsmith, C.H]]
[[Category: Santhakumar, V]]
[[Category: Dong, A]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Li, Y]]
[[Category: Halabelian, L]]
[[Category: Kimani, S]]
[[Category: Zeng, H]]