OCA at 13:14, 13 March 2024

OCA — Wed, 13 Mar 2024 13:14:17 GMT

←Older revision		Revision as of 13:14, 13 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8gdr is ~~ON HOLD~~	+	==SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21B10==
-		+	<StructureSection load='8gdr' size='340' side='right'caption='[[8gdr]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~: ~~Patel~~, A., ~~Ortlund~~, E.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8gdr]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GDR FirstGlance]. <br>
-	~~Description~~: ~~SARS~~-~~Cov2 S~~ protein structure in ~~complex with neutralizing monoclonal antibody 002~~-~~S21B10~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: Ortlund~~, E.A~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gdr OCA], [https://pdbe.org/8gdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gdr RCSB], [https://www.ebi.ac.uk/pdbsum/8gdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gdr ProSAT]</span></td></tr>
-	[[Category: Patel, A]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Ortlund EA]]
		+	[[Category: Patel A]]

OCA at 04:56, 7 April 2023

OCA — Fri, 07 Apr 2023 04:56:10 GMT

←Older revision		Revision as of 04:56, 7 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gdr is ON HOLD ~~until sometime in the future~~	+	The entry 8gdr is ON HOLD

	Authors: Patel, A., Ortlund, E.A.		Authors: Patel, A., Ortlund, E.A.

OCA: Protected "8gdr" [edit=sysop:move=sysop]

OCA — Wed, 15 Mar 2023 07:47:09 GMT

Protected "8gdr" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:47, 15 March 2023

OCA: New page: '''Unreleased structure''' The entry 8gdr is ON HOLD until sometime in the future Authors: Patel, A., Ortlund, E.A. Description: SARS-Cov2 S protein structure in complex with neutraliz...

OCA — Wed, 15 Mar 2023 07:47:08 GMT

New page: '''Unreleased structure''' The entry 8gdr is ON HOLD until sometime in the future Authors: Patel, A., Ortlund, E.A. Description: SARS-Cov2 S protein structure in complex with neutraliz...

New page

'''Unreleased structure'''

The entry 8gdr is ON HOLD until sometime in the future

Authors: Patel, A., Ortlund, E.A.

Description: SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21B10
[[Category: Unreleased Structures]]
[[Category: Ortlund, E.A]]
[[Category: Patel, A]]

8gdr - Revision history

OCA at 13:14, 13 March 2024

OCA at 04:56, 7 April 2023

OCA: Protected "8gdr" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8gdr is ON HOLD until sometime in the future Authors: Patel, A., Ortlund, E.A. Description: SARS-Cov2 S protein structure in complex with neutraliz...