OCA at 11:59, 8 November 2023

OCA — Wed, 08 Nov 2023 11:59:54 GMT

←Older revision		Revision as of 11:59, 8 November 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8gf7 is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils==
-		+	<StructureSection load='8gf7' size='340' side='right'caption='[[8gf7]], [[Resolution\|resolution]] 4.80Å' scene=''>
-	~~Authors~~: ~~Balana~~, J.A., ~~Nguyen~~, A.B., ~~Saelices~~, L., ~~Pratt~~, R.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8gf7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GF7 FirstGlance]. <br>
-	~~Description~~: ~~Cryo-EM structure~~ of ~~serine 87 O~~-~~GlcNAc~~-~~modified alpha-synuclein fibrils~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.8Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Pratt, R.M~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gf7 OCA], [https://pdbe.org/8gf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gf7 RCSB], [https://www.ebi.ac.uk/pdbsum/8gf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gf7 ProSAT]</span></td></tr>
-	[[Category: ~~Saelices, L~~]]	+	</table>
-	[[Category: Nguyen~~, A.B~~]]	+	== Disease ==
-	[[Category: ~~Balana, J.A~~]]	+	[https://www.uniprot.org/uniprot/SYUA_HUMAN SYUA_HUMAN] Note=Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer disease amyloid plaque, and a major component of Lewy body inclusions. They are also found within Lewy body (LB)-like intraneuronal inclusions, glial inclusions and axonal spheroids in neurodegeneration with brain iron accumulation type 1. Defects in SNCA are the cause of Parkinson disease type 1 (PARK1) [MIM:[https://omim.org/entry/168601 168601]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.<ref>PMID:9197268</ref> <ref>PMID:9462735</ref> <ref>PMID:14755719</ref> Defects in SNCA are the cause of Parkinson disease type 4 (PARK4) [MIM:[https://omim.org/entry/605543 605543]. A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia. Defects in SNCA are the cause of dementia Lewy body (DLB) [MIM:[https://omim.org/entry/127750 127750]. A neurodegenerative disorder clinically characterized by mental impairment leading to dementia, parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Brainstem or cortical intraneuronal accumulations of aggregated proteins (Lewy bodies) are the only essential pathologic features. Patients may also have hippocampal and neocortical senile plaques, sometimes in sufficient number to fulfill the diagnostic criteria for Alzheimer disease.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYUA_HUMAN SYUA_HUMAN] May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Balana JA]]
		+	[[Category: Nguyen AB]]
		+	[[Category: Pratt RM]]
		+	[[Category: Saelices L]]

OCA at 02:19, 25 May 2023

OCA — Thu, 25 May 2023 02:19:29 GMT

←Older revision		Revision as of 02:19, 25 May 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gf7 is ON HOLD	+	The entry 8gf7 is ON HOLD until Paper Publication

	Authors: Balana, J.A., Nguyen, A.B., Saelices, L., Pratt, R.M.		Authors: Balana, J.A., Nguyen, A.B., Saelices, L., Pratt, R.M.
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	Description: Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils		Description: Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Saelices, L]]
-	[[Category: Balana, J.A]]
	[[Category: Pratt, R.M]]		[[Category: Pratt, R.M]]
		+	[[Category: Saelices, L]]
	[[Category: Nguyen, A.B]]		[[Category: Nguyen, A.B]]
		+	[[Category: Balana, J.A]]

OCA: Protected "8gf7" [edit=sysop:move=sysop]

OCA — Wed, 15 Mar 2023 07:51:36 GMT

Protected "8gf7" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:51, 15 March 2023

OCA: New page: '''Unreleased structure''' The entry 8gf7 is ON HOLD Authors: Balana, J.A., Nguyen, A.B., Saelices, L., Pratt, R.M. Description: Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-...

OCA — Wed, 15 Mar 2023 07:51:35 GMT

New page: '''Unreleased structure''' The entry 8gf7 is ON HOLD Authors: Balana, J.A., Nguyen, A.B., Saelices, L., Pratt, R.M. Description: Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-...

New page

'''Unreleased structure'''

The entry 8gf7 is ON HOLD

Authors: Balana, J.A., Nguyen, A.B., Saelices, L., Pratt, R.M.

Description: Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils
[[Category: Unreleased Structures]]
[[Category: Saelices, L]]
[[Category: Balana, J.A]]
[[Category: Pratt, R.M]]
[[Category: Nguyen, A.B]]

8gf7 - Revision history

OCA at 11:59, 8 November 2023

OCA at 02:19, 25 May 2023

OCA: Protected "8gf7" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8gf7 is ON HOLD Authors: Balana, J.A., Nguyen, A.B., Saelices, L., Pratt, R.M. Description: Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-...