OCA at 12:04, 6 March 2024

OCA — Wed, 06 Mar 2024 12:04:13 GMT

←Older revision		Revision as of 12:04, 6 March 2024
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-	'''Unreleased structure'''

-	The entry ~~8gg9~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #15 of 20)==
-		+	<StructureSection load='8gg9' size='340' side='right'caption='[[8gg9]], [[Resolution\|resolution]] 3.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8gg9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GG9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G1I:(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol'>G1I</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gg9 OCA], [https://pdbe.org/8gg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gg9 RCSB], [https://www.ebi.ac.uk/pdbsum/8gg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gg9 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Papasergi-Scott MM]]
		+	[[Category: Skiniotis G]]

OCA at 05:07, 7 February 2024

OCA — Wed, 07 Feb 2024 05:07:11 GMT

←Older revision		Revision as of 05:07, 7 February 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gg9 is ON HOLD	+	The entry 8gg9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 22:00, 27 December 2023

OCA — Wed, 27 Dec 2023 22:00:40 GMT

←Older revision		Revision as of 22:00, 27 December 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gg9 is ON HOLD ~~until Paper Publication~~	+	The entry 8gg9 is ON HOLD

	Authors:		Authors:

OCA at 18:39, 12 April 2023

OCA — Wed, 12 Apr 2023 18:39:09 GMT

←Older revision		Revision as of 18:39, 12 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gg9 is ON HOLD	+	The entry 8gg9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8gg9" [edit=sysop:move=sysop]

OCA — Wed, 15 Mar 2023 07:54:56 GMT

Protected "8gg9" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:54, 15 March 2023

OCA: New page: '''Unreleased structure''' The entry 8gg9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Mar 2023 07:54:54 GMT

New page: '''Unreleased structure''' The entry 8gg9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page