8gih - Revision history

OCA at 10:34, 25 October 2023

OCA — Wed, 25 Oct 2023 10:34:19 GMT

←Older revision		Revision as of 10:34, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8gih]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[8gih]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GIH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZMH:(6S,8R)-N-(3-bromo-4-fluorophenyl)-8-fluoro-10-methyl-11-oxo-1,3,4,7,8,9,10,11-octahydro-2H-pyrido[4,3 3,4]pyrazolo[1,5-a][1,4]diazepine-2-carboxamide'>ZMH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZMH:(6S,8R)-N-(3-bromo-4-fluorophenyl)-8-fluoro-10-methyl-11-oxo-1,3,4,7,8,9,10,11-octahydro-2H-pyrido[4,3 3,4]pyrazolo[1,5-a][1,4]diazepine-2-carboxamide'>ZMH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gih OCA], [https://pdbe.org/8gih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gih RCSB], [https://www.ebi.ac.uk/pdbsum/8gih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gih ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gih OCA], [https://pdbe.org/8gih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gih RCSB], [https://www.ebi.ac.uk/pdbsum/8gih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gih ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:34, 12 April 2023

OCA — Wed, 12 Apr 2023 20:34:04 GMT

←Older revision		Revision as of 20:34, 12 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8gih is ~~ON HOLD~~	+	==Structure of Hepatitis B Virus Capsid Y132A mutant in complex with Compound 24==
		+	<StructureSection load='8gih' size='340' side='right'caption='[[8gih]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8gih]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GIH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZMH:(6S,8R)-N-(3-bromo-4-fluorophenyl)-8-fluoro-10-methyl-11-oxo-1,3,4,7,8,9,10,11-octahydro-2H-pyrido[4,3 3,4]pyrazolo[1,5-a][1,4]diazepine-2-carboxamide'>ZMH</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gih OCA], [https://pdbe.org/8gih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gih RCSB], [https://www.ebi.ac.uk/pdbsum/8gih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gih ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/L7R9I1_HBV L7R9I1_HBV]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials with small molecule capsid assembly modulators (CAMs). Herein is described the further optimization of a progressive series of diazepinone HBV CAMs.

-	~~Authors: Shaffer~~, P.L.	+	Diazepinone HBV capsid assembly modulators.,Kuduk SD, DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Hartman GD Bioorg Med Chem Lett. 2022 Sep 15;72:128823. doi: 10.1016/j.bmcl.2022.128823. , Epub 2022 May 27. PMID:35644301<ref>PMID:35644301</ref>

-	~~Description: Structure~~ of Hepatitis B ~~Virus Capsid Y132A mutant in complex with Compound 24~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Shaffer~~, P.L~~]]	+	<div class="pdbe-citations 8gih" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hepatitis B virus]]
		+	[[Category: Large Structures]]
		+	[[Category: Shaffer PL]]

OCA: Protected "8gih" [edit=sysop:move=sysop]

OCA — Wed, 22 Mar 2023 05:42:41 GMT

Protected "8gih" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 22 March 2023

OCA: New page: '''Unreleased structure''' The entry 8gih is ON HOLD Authors: Shaffer, P.L. Description: Structure of Hepatitis B Virus Capsid Y132A mutant in complex with Compound 24 [[Category: Unre...

OCA — Wed, 22 Mar 2023 05:42:40 GMT

New page: '''Unreleased structure''' The entry 8gih is ON HOLD Authors: Shaffer, P.L. Description: Structure of Hepatitis B Virus Capsid Y132A mutant in complex with Compound 24 [[Category: Unre...

New page

'''Unreleased structure'''

The entry 8gih is ON HOLD

Authors: Shaffer, P.L.

Description: Structure of Hepatitis B Virus Capsid Y132A mutant in complex with Compound 24
[[Category: Unreleased Structures]]
[[Category: Shaffer, P.L]]