8gn6 - Revision history

OCA at 19:49, 29 May 2024

OCA — Wed, 29 May 2024 19:49:36 GMT

←Older revision		Revision as of 19:49, 29 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8gn6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GN6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8gn6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GN6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gn6 OCA], [https://pdbe.org/8gn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gn6 RCSB], [https://www.ebi.ac.uk/pdbsum/8gn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gn6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gn6 OCA], [https://pdbe.org/8gn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gn6 RCSB], [https://www.ebi.ac.uk/pdbsum/8gn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gn6 ProSAT]</span></td></tr>
	</table>		</table>
-	== Function ==
-	[https://www.uniprot.org/uniprot/A0A1R4DV85_PORGN A0A1R4DV85_PORGN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:28, 19 April 2023

OCA — Wed, 19 Apr 2023 09:28:00 GMT

←Older revision		Revision as of 09:28, 19 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8gn6 is ~~ON HOLD until Paper~~ Publication	+	==Crystallization of Sialidase from Porphyromonas gingivalis==
		+	<StructureSection load='8gn6' size='340' side='right'caption='[[8gn6]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8gn6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GN6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gn6 OCA], [https://pdbe.org/8gn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gn6 RCSB], [https://www.ebi.ac.uk/pdbsum/8gn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gn6 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1R4DV85_PORGN A0A1R4DV85_PORGN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The sialidases, which catalyze the hydrolysis of sialic acid from extracellular glycoconjugates, are a group of major virulence factors in various pathogenic bacteria. In Porphyromonas gingivalis, which causes human periodontal disease, sialidase contributes to bacterial pathogenesis via promoting the formation of biofilms and capsules, reducing the ability for macrophage clearance, and providing nutrients for bacterial colonization. Here, the crystal structure of the P. gingivalis sialidase SiaPG is reported at 2.1 A resolution, revealing an N-terminal carbohydrate-binding domain followed by a canonical C-terminal catalytic domain. Simulation of the product sialic acid in the active-site pocket together with functional analysis enables clear identification of the key residues that are required for substrate binding and catalysis. Moreover, structural comparison with other sialidases reveals distinct features of the active-site pocket which might confer substrate specificity. These findings provide the structural basis for the further design and optimization of effective inhibitors to target SiaPG to fight against P. gingivalis-derived oral diseases.

-	~~Authors:~~ Dong, W.B.	+	Structural and enzymatic characterization of the sialidase SiaPG from Porphyromonas gingivalis.,Dong WB, Jiang YL, Zhu ZL, Zhu J, Li Y, Xia R, Zhou K Acta Crystallogr F Struct Biol Commun. 2023 Apr 1;79(Pt 4):87-94. doi: , 10.1107/S2053230X23001735. Epub 2023 Mar 30. PMID:36995120<ref>PMID:36995120</ref>

-	~~Description: Crystallization~~ of ~~Sialidase from Porphyromonas gingivalis~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Dong~~, W.B~~]]	+	<div class="pdbe-citations 8gn6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Porphyromonas gingivalis]]
		+	[[Category: Dong WB]]

OCA at 08:50, 15 February 2023

OCA — Wed, 15 Feb 2023 08:50:48 GMT

←Older revision		Revision as of 08:50, 15 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gn6 is ON HOLD	+	The entry 8gn6 is ON HOLD until Paper Publication

	Authors: Dong, W.B.		Authors: Dong, W.B.

OCA at 07:50, 14 December 2022

OCA — Wed, 14 Dec 2022 07:50:03 GMT

←Older revision		Revision as of 07:50, 14 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gn6 is ON HOLD ~~until Paper Publication~~	+	The entry 8gn6 is ON HOLD

	Authors: Dong, W.B.		Authors: Dong, W.B.

OCA at 05:52, 14 September 2022

OCA — Wed, 14 Sep 2022 05:52:44 GMT

←Older revision		Revision as of 05:52, 14 September 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gn6 is ON HOLD	+	The entry 8gn6 is ON HOLD until Paper Publication

	Authors: Dong, W.B.		Authors: Dong, W.B.

OCA: Protected "8gn6" [edit=sysop:move=sysop]

OCA — Wed, 31 Aug 2022 05:41:05 GMT

Protected "8gn6" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 31 August 2022

OCA: New page: '''Unreleased structure''' The entry 8gn6 is ON HOLD Authors: Dong, W.B. Description: Crystallization of Sialidase from Porphyromonas gingivalis Category: Unreleased Structures [[C...

OCA — Wed, 31 Aug 2022 05:41:04 GMT

New page: '''Unreleased structure''' The entry 8gn6 is ON HOLD Authors: Dong, W.B. Description: Crystallization of Sialidase from Porphyromonas gingivalis Category: Unreleased Structures [[C...

New page

'''Unreleased structure'''

The entry 8gn6 is ON HOLD

Authors: Dong, W.B.

Description: Crystallization of Sialidase from Porphyromonas gingivalis
[[Category: Unreleased Structures]]
[[Category: Dong, W.B]]