8gqz - Revision history

OCA at 19:49, 29 May 2024

OCA — Wed, 29 May 2024 19:49:43 GMT

←Older revision		Revision as of 19:49, 29 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8gqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GQZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[8gqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GQZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.42Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gqz OCA], [https://pdbe.org/8gqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gqz RCSB], [https://www.ebi.ac.uk/pdbsum/8gqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gqz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gqz OCA], [https://pdbe.org/8gqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gqz RCSB], [https://www.ebi.ac.uk/pdbsum/8gqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[https://www.uniprot.org/uniprot/~~A0A6A5Q7J3_YEASX A0A6A5Q7J3_YEASX~~]	+	[https://www.uniprot.org/uniprot/CISY1_YEAST CISY1_YEAST] Specific citrate synthase with catalytic activity only with acetyl-CoA.<ref>PMID:17570335</ref> <ref>PMID:28076776</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:08, 26 April 2023

OCA — Wed, 26 Apr 2023 17:08:26 GMT

←Older revision		Revision as of 17:08, 26 April 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8gqz is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of mitochondrial citrate synthase (Cit1) from Saccharomyces cerevisiae==
		+	<StructureSection load='8gqz' size='340' side='right'caption='[[8gqz]], [[Resolution\|resolution]] 1.42Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8gqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GQZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gqz OCA], [https://pdbe.org/8gqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gqz RCSB], [https://www.ebi.ac.uk/pdbsum/8gqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gqz ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A6A5Q7J3_YEASX A0A6A5Q7J3_YEASX]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Deficiencies in mitochondrial protein import are associated with a number of diseases. However, although nonimported mitochondrial proteins are at great risk of aggregation, it remains largely unclear how their accumulation causes cell dysfunction. Here, we show that nonimported citrate synthase is targeted for proteasomal degradation by the ubiquitin ligase SCF(Ucc1). Unexpectedly, our structural and genetic analyses revealed that nonimported citrate synthase appears to form an enzymatically active conformation in the cytosol. Its excess accumulation caused ectopic citrate synthesis, which, in turn, led to an imbalance in carbon flux of sugar, a reduction of the pool of amino acids and nucleotides, and a growth defect. Under these conditions, translation repression is induced and acts as a protective mechanism that mitigates the growth defect. We propose that the consequence of mitochondrial import failure is not limited to proteotoxic insults, but that the accumulation of a nonimported metabolic enzyme elicits ectopic metabolic stress.

-	~~Authors~~:	+	Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress.,Nishio K, Kawarasaki T, Sugiura Y, Matsumoto S, Konoshima A, Takano Y, Hayashi M, Okumura F, Kamura T, Mizushima T, Nakatsukasa K Sci Adv. 2023 Apr 14;9(15):eadf1956. doi: 10.1126/sciadv.adf1956. Epub 2023 Apr , 14. PMID:37058555<ref>PMID:37058555</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8gqz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Kamura T]]
		+	[[Category: Mizushima T]]
		+	[[Category: Nakatsukasa K]]
		+	[[Category: Nishio K]]

OCA at 17:33, 19 October 2022

OCA — Wed, 19 Oct 2022 17:33:58 GMT

←Older revision		Revision as of 17:33, 19 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gqz is ON HOLD	+	The entry 8gqz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8gqz" [edit=sysop:move=sysop]

OCA — Wed, 07 Sep 2022 15:41:44 GMT

Protected "8gqz" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:41, 7 September 2022

OCA: New page: '''Unreleased structure''' The entry 8gqz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 07 Sep 2022 15:41:43 GMT

New page: '''Unreleased structure''' The entry 8gqz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8gqz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]