8gy5 - Revision history

OCA at 12:33, 4 October 2023

OCA — Wed, 04 Oct 2023 12:33:35 GMT

←Older revision		Revision as of 12:33, 4 October 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8gy5 is ~~ON HOLD until Paper Publication~~	+	==High-resolution structure of the cemiplimab Fab in complex with PD-1==
-		+	<StructureSection load='8gy5' size='340' side='right'caption='[[8gy5]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~Authors~~: ~~Heo~~, Y.-S., ~~Jeong~~, T.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8gy5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GY5 FirstGlance]. <br>
-	~~Description~~: ~~High-resolution structure~~ of the ~~cemiplimab Fab~~ in ~~complex~~ with PD-1	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gy5 OCA], [https://pdbe.org/8gy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gy5 RCSB], [https://www.ebi.ac.uk/pdbsum/8gy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gy5 ProSAT]</span></td></tr>
-	[[Category: ~~Jeong, T.J~~]]	+	</table>
-	[[Category: Heo, Y.-S]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[https://omim.org/entry/605218 605218]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Heo Y-S]]
		+	[[Category: Jeong TJ]]

OCA at 05:30, 3 November 2022

OCA — Thu, 03 Nov 2022 05:30:45 GMT

←Older revision		Revision as of 05:30, 3 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8gy5 is ON HOLD	+	The entry 8gy5 is ON HOLD until Paper Publication

	Authors: Heo, Y.-S., Jeong, T.J.		Authors: Heo, Y.-S., Jeong, T.J.
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	Description: High-resolution structure of the cemiplimab Fab in complex with PD-1		Description: High-resolution structure of the cemiplimab Fab in complex with PD-1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Heo, Y.-S]]
	[[Category: Jeong, T.J]]		[[Category: Jeong, T.J]]
		+	[[Category: Heo, Y.-S]]

OCA: Protected "8gy5" [edit=sysop:move=sysop]

OCA — Wed, 28 Sep 2022 04:53:55 GMT

Protected "8gy5" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:53, 28 September 2022

OCA: New page: '''Unreleased structure''' The entry 8gy5 is ON HOLD Authors: Heo, Y.-S., Jeong, T.J. Description: High-resolution structure of the cemiplimab Fab in complex with PD-1 [[Category: Unre...

OCA — Wed, 28 Sep 2022 04:53:54 GMT

New page: '''Unreleased structure''' The entry 8gy5 is ON HOLD Authors: Heo, Y.-S., Jeong, T.J. Description: High-resolution structure of the cemiplimab Fab in complex with PD-1 [[Category: Unre...

New page

'''Unreleased structure'''

The entry 8gy5 is ON HOLD

Authors: Heo, Y.-S., Jeong, T.J.

Description: High-resolution structure of the cemiplimab Fab in complex with PD-1
[[Category: Unreleased Structures]]
[[Category: Heo, Y.-S]]
[[Category: Jeong, T.J]]