OCA at 05:46, 5 July 2023

OCA — Wed, 05 Jul 2023 05:46:21 GMT

←Older revision		Revision as of 05:46, 5 July 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8h0n is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of the human METTL1-WDR4 complex==
-		+	<StructureSection load='8h0n' size='340' side='right'caption='[[8h0n]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8h0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H0N FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h0n OCA], [https://pdbe.org/8h0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h0n RCSB], [https://www.ebi.ac.uk/pdbsum/8h0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h0n ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/WDR4_HUMAN WDR4_HUMAN] Galloway-Mowat syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/WDR4_HUMAN WDR4_HUMAN] Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (PubMed:12403464). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069).<ref>PMID:12403464</ref> <ref>PMID:26751069</ref> <ref>PMID:31031083</ref> <ref>PMID:31031084</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Gong Z]]
		+	[[Category: Guan ZY]]
		+	[[Category: Jin XH]]
		+	[[Category: Zhang DL]]

OCA: Protected "8h0n" [edit=sysop:move=sysop]

OCA — Thu, 03 Nov 2022 05:31:57 GMT

Protected "8h0n" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:31, 3 November 2022

OCA: New page: '''Unreleased structure''' The entry 8h0n is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Thu, 03 Nov 2022 05:31:56 GMT

New page: '''Unreleased structure''' The entry 8h0n is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8h0n is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

8h0n - Revision history

OCA at 05:46, 5 July 2023

OCA: Protected "8h0n" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8h0n is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures