OCA at 05:58, 11 October 2023

OCA — Wed, 11 Oct 2023 05:58:26 GMT

←Older revision		Revision as of 05:58, 11 October 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 8h4r ~~is ON HOLD~~	+	==The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus==
-		+	<StructureSection load='8h4r' size='340' side='right'caption='[[8h4r]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~Authors~~: ~~Gui~~, W., ~~Wang~~, F., ~~Cheng~~, W., ~~Gao~~, J., ~~Huang~~, Y., ~~Ouyang, Z~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8h4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H4R FirstGlance]. <br>
-	~~Description~~: ~~The Crystal Structure~~ of ~~CDK3~~ and ~~CyclinE1 Complex~~ with ~~Dinaciclib from Biortus~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1QK:3-[({3-ETHYL-5-[(2S)-2-(2-HYDROXYETHYL)PIPERIDIN-1-YL]PYRAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)METHYL]-1-HYDROXYPYRIDINIUM'>1QK</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	[[Category: ~~Gui,~~ W]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h4r OCA], [https://pdbe.org/8h4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h4r RCSB], [https://www.ebi.ac.uk/pdbsum/8h4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h4r ProSAT]</span></td></tr>
-	[[Category: ~~Ouyang, Z~~]]	+	</table>
-	[[Category: ~~Huang, Y~~]]	+	== Function ==
-	[[Category: ~~Wang, F~~]]	+	[https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.[https://www.uniprot.org/uniprot/CDK3_HUMAN CDK3_HUMAN] Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.<ref>PMID:15084261</ref> <ref>PMID:18794154</ref> <ref>PMID:8846921</ref>
-	[[Category: ~~Cheng, W~~]]	+	== References ==
-	[[Category: ~~Gao, J~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Schistosoma japonicum]]
		+	[[Category: Cheng W]]
		+	[[Category: Gao J]]
		+	[[Category: Gui W]]
		+	[[Category: Huang Y]]
		+	[[Category: Ouyang Z]]
		+	[[Category: Wang F]]

OCA: Protected "8h4r" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2022 17:49:55 GMT

Protected "8h4r" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:49, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8h4r is ON HOLD Authors: Gui, W., Wang, F., Cheng, W., Gao, J., Huang, Y., Ouyang, Z. Description: The Crystal Structure of CDK3 and CyclinE1 Compl...

OCA — Wed, 19 Oct 2022 17:49:54 GMT

New page: '''Unreleased structure''' The entry 8h4r is ON HOLD Authors: Gui, W., Wang, F., Cheng, W., Gao, J., Huang, Y., Ouyang, Z. Description: The Crystal Structure of CDK3 and CyclinE1 Compl...

New page

'''Unreleased structure'''

The entry 8h4r is ON HOLD

Authors: Gui, W., Wang, F., Cheng, W., Gao, J., Huang, Y., Ouyang, Z.

Description: The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus
[[Category: Unreleased Structures]]
[[Category: Gui, W]]
[[Category: Ouyang, Z]]
[[Category: Huang, Y]]
[[Category: Wang, F]]
[[Category: Cheng, W]]
[[Category: Gao, J]]

8h4r - Revision history

OCA at 05:58, 11 October 2023

OCA: Protected "8h4r" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8h4r is ON HOLD Authors: Gui, W., Wang, F., Cheng, W., Gao, J., Huang, Y., Ouyang, Z. Description: The Crystal Structure of CDK3 and CyclinE1 Compl...