8hdh - Revision history

OCA at 12:00, 8 November 2023

OCA — Wed, 08 Nov 2023 12:00:46 GMT

←Older revision		Revision as of 12:00, 8 November 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8hdh is ~~ON HOLD until 2024~~-~~11-04~~	+	==Structure of human SGLT2-MAP17 complex with Canagliflozin==
-		+	<StructureSection load='8hdh' size='340' side='right'caption='[[8hdh]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~Authors~~: ~~Masahiro~~, H., ~~Hioryuki~~, K., ~~Ikuko~~, M., ~~Osamu~~, N.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hdh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HDH FirstGlance]. <br>
-	~~Description~~: ~~Structure of human SGLT2~~-~~MAP17 complex~~ with ~~Canagliflozin~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L3R:(2~{S},3~{R},4~{R},5~{S},6~{R})-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methyl-phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol'>L3R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: Hioryuki, K]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hdh OCA], [https://pdbe.org/8hdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hdh RCSB], [https://www.ebi.ac.uk/pdbsum/8hdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hdh ProSAT]</span></td></tr>
-	[[Category: ~~Masahiro, H~~]]	+	</table>
-	[[Category: ~~Ikuko, M~~]]	+	== Disease ==
-	[[Category: Osamu, N]]	+	[https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Familial renal glucosuria. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).[UniProtKB:Q923I7]<ref>PMID:20980548</ref> <ref>PMID:28592437</ref> <ref>PMID:34880493</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Hioryuki K]]
		+	[[Category: Ikuko M]]
		+	[[Category: Masahiro H]]
		+	[[Category: Osamu N]]

OCA at 07:55, 14 December 2022

OCA — Wed, 14 Dec 2022 07:55:18 GMT

←Older revision		Revision as of 07:55, 14 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hdh is ON HOLD	+	The entry 8hdh is ON HOLD until 2024-11-04

	Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N.		Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N.
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	Description: Structure of human SGLT2-MAP17 complex with Canagliflozin		Description: Structure of human SGLT2-MAP17 complex with Canagliflozin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ikuko, M]]
-	[[Category: Osamu, N]]
	[[Category: Hioryuki, K]]		[[Category: Hioryuki, K]]
	[[Category: Masahiro, H]]		[[Category: Masahiro, H]]
		+	[[Category: Ikuko, M]]
		+	[[Category: Osamu, N]]

OCA: Protected "8hdh" [edit=sysop:move=sysop]

OCA — Wed, 09 Nov 2022 05:20:09 GMT

Protected "8hdh" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:20, 9 November 2022

OCA: New page: '''Unreleased structure''' The entry 8hdh is ON HOLD Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N. Description: Structure of human SGLT2-MAP17 complex with Canagliflozin [[...

OCA — Wed, 09 Nov 2022 05:20:08 GMT

New page: '''Unreleased structure''' The entry 8hdh is ON HOLD Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N. Description: Structure of human SGLT2-MAP17 complex with Canagliflozin [[...

New page

'''Unreleased structure'''

The entry 8hdh is ON HOLD

Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N.

Description: Structure of human SGLT2-MAP17 complex with Canagliflozin
[[Category: Unreleased Structures]]
[[Category: Ikuko, M]]
[[Category: Osamu, N]]
[[Category: Hioryuki, K]]
[[Category: Masahiro, H]]