OCA at 13:08, 1 November 2023

OCA — Wed, 01 Nov 2023 13:08:46 GMT

←Older revision		Revision as of 13:08, 1 November 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hey is ~~ON HOLD until Paper~~ Publication	+	==One CVSC-binding penton vertex in HCMV B-capsid==
		+	<StructureSection load='8hey' size='340' side='right'caption='[[8hey]], [[Resolution\|resolution]] 4.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8hey]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HEY FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hey OCA], [https://pdbe.org/8hey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hey RCSB], [https://www.ebi.ac.uk/pdbsum/8hey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hey ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8T7C4_HCMV A8T7C4_HCMV] Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the major capsid protein and small capsomere-interacting protein/SCP assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.[HAMAP-Rule:MF_04021]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The portal-scaffold complex is believed to nucleate the assembly of herpesvirus procapsids. During capsid maturation, two events occur: scaffold expulsion and DNA incorporation. The portal-scaffold interaction and the conformational changes that occur to the portal during the different stages of capsid formation have yet to be elucidated structurally. Here we present high-resolution structures of the A- and B-capsids and in-situ portals of human cytomegalovirus. We show that scaffolds bind to the hydrophobic cavities formed by the dimerization and Johnson-fold domains of the major capsid proteins. We further show that 12 loop-helix-loop fragments-presumably from the scaffold domain-insert into the hydrophobic pocket of the portal crown domain. The portal also undergoes significant changes both positionally and conformationally as it accompanies DNA packaging. These findings unravel the mechanism by which the portal interacts with the scaffold to nucleate capsid assembly and further our understanding of scaffold expulsion and DNA incorporation.

-	~~Authors: Li~~, Z., Yu, X.	+	Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus.,Li Z, Pang J, Gao R, Wang Q, Zhang M, Yu X Nat Commun. 2023 Apr 11;14(1):2025. doi: 10.1038/s41467-023-37779-0. PMID:37041152<ref>PMID:37041152</ref>

-	~~Description: One CVSC~~-~~binding penton vertex in HCMV B~~-~~capsid~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Yu, X~~]]	+	<div class="pdbe-citations 8hey" style="background-color:#fffaf0;"></div>
-	[[Category: Li, Z]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human betaherpesvirus 5]]
		+	[[Category: Large Structures]]
		+	[[Category: Li Z]]
		+	[[Category: Yu X]]

OCA at 06:57, 21 December 2022

OCA — Wed, 21 Dec 2022 06:57:30 GMT

←Older revision		Revision as of 06:57, 21 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hey is ON HOLD	+	The entry 8hey is ON HOLD until Paper Publication

	Authors: Li, Z., Yu, X.		Authors: Li, Z., Yu, X.

OCA at 08:48, 30 November 2022

OCA — Wed, 30 Nov 2022 08:48:34 GMT

←Older revision		Revision as of 08:48, 30 November 2022
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	Authors: Li, Z., Yu, X.		Authors: Li, Z., Yu, X.

-	Description: ~~one~~ CVSC-binding penton vertex in HCMV B-capsid	+	Description: One CVSC-binding penton vertex in HCMV B-capsid
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yu, X]]		[[Category: Yu, X]]
	[[Category: Li, Z]]		[[Category: Li, Z]]

OCA: Protected "8hey" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2022 18:28:46 GMT

Protected "8hey" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:28, 16 November 2022

OCA: New page: '''Unreleased structure''' The entry 8hey is ON HOLD Authors: Li, Z., Yu, X. Description: one CVSC-binding penton vertex in HCMV B-capsid Category: Unreleased Structures [[Category...

OCA — Wed, 16 Nov 2022 18:28:45 GMT

New page: '''Unreleased structure''' The entry 8hey is ON HOLD Authors: Li, Z., Yu, X. Description: one CVSC-binding penton vertex in HCMV B-capsid Category: Unreleased Structures [[Category...

New page

'''Unreleased structure'''

The entry 8hey is ON HOLD

Authors: Li, Z., Yu, X.

Description: one CVSC-binding penton vertex in HCMV B-capsid
[[Category: Unreleased Structures]]
[[Category: Yu, X]]
[[Category: Li, Z]]

8hey - Revision history

OCA at 13:08, 1 November 2023

OCA at 06:57, 21 December 2022

OCA at 08:48, 30 November 2022

OCA: Protected "8hey" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8hey is ON HOLD Authors: Li, Z., Yu, X. Description: one CVSC-binding penton vertex in HCMV B-capsid Category: Unreleased Structures [[Category...