8hez - Revision history

OCA at 16:13, 13 December 2023

OCA — Wed, 13 Dec 2023 16:13:31 GMT

←Older revision		Revision as of 16:13, 13 December 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hez is ~~ON HOLD until 2024~~-~~11-09~~	+	==Structure of human SGLT2-MAP17 complex with Dapagliflozin==
-		+	<StructureSection load='8hez' size='340' side='right'caption='[[8hez]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Hiraizumi~~, M., ~~Kishida~~, H., ~~Miyaguchi~~, I., ~~Nureki~~, O.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HEZ FirstGlance]. <br>
-	~~Description~~: ~~Structure of human SGLT2~~-~~MAP17 complex~~ with ~~Dapagliflozin~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LE6:(2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol'>LE6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Nureki, O~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hez OCA], [https://pdbe.org/8hez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hez RCSB], [https://www.ebi.ac.uk/pdbsum/8hez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hez ProSAT]</span></td></tr>
-	[[Category: Kishida, H]]	+	</table>
-	[[Category: Miyaguchi, I]]	+	== Disease ==
-	[[Category: ~~Hiraizumi, M~~]]	+	[https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Familial renal glucosuria. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).[UniProtKB:Q923I7]<ref>PMID:20980548</ref> <ref>PMID:28592437</ref> <ref>PMID:34880493</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Hiraizumi M]]
		+	[[Category: Kishida H]]
		+	[[Category: Miyaguchi I]]
		+	[[Category: Nureki O]]

OCA at 05:30, 22 November 2023

OCA — Wed, 22 Nov 2023 05:30:46 GMT

←Older revision		Revision as of 05:30, 22 November 2023
Line 1:		Line 1:
		+	'''Unreleased structure'''

-	~~==Structure of human SGLT2-MAP17 complex with Dapagliflozin==~~	+	The entry 8hez is ON HOLD until 2024-11-09
-	~~<StructureSection load='~~8hez~~' size='340' side='right'caption='[[8hez]], [[Resolution\|resolution]] 2.80Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+	Authors: Hiraizumi, M., Kishida, H., Miyaguchi, I., Nureki, O.
-	~~<table><tr><td colspan='2'>[[8hez]]~~ is ~~a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca~~-~~bin/ocashort?id=8HEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HEZ FirstGlance]. <br>~~	+
-	~~</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method~~:~~]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy~~, ~~[[Resolution\|Resolution]] 2~~.~~8Å</td></tr>~~	+	Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin
-	~~<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LE6:(2S~~,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol'>LE6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	[[Category: Unreleased Structures]]
-	~~<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia~~.~~org/fgij/fg.htm?mol=8hez FirstGlance]~~, ~~[http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hez OCA]~~, ~~[https://pdbe~~.~~org/8hez PDBe]~~, ~~[https://www.rcsb.org/pdb/explore.do?structureId=8hez RCSB]~~, ~~[https://www~~.~~ebi.ac.uk/pdbsum/8hez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hez ProSAT]</span></td></tr>~~	+	[[Category: Nureki, O]]
-	~~</table>~~	+	[[Category: Kishida, H]]
-	~~== Disease ==~~	+	[[Category: Miyaguchi, I]]
-	~~[https~~:~~//www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Familial renal glucosuria. The disease is caused by variants affecting the gene represented in this entry.~~	+	[[Category: Hiraizumi, M]]
-	~~== Function ==~~	+
-	~~[https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Electrogenic Na(+)~~-~~coupled sugar simporter that actively transports D-glucose at the plasma membrane,~~ with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).[UniProtKB:Q923I7]<ref>PMID:20980548</ref> <ref>PMID:28592437</ref> <ref>PMID:34880493</ref>	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	[[Category: ~~Homo sapiens]]~~	+
-	~~[[Category: Large~~ Structures]]	+
-	[[Category: ~~Hiraizumi M~~]]	+
-	[[Category: Kishida H]]	+
-	[[Category: Miyaguchi I]]	+
-	[[Category: ~~Nureki O~~]]	+

OCA at 07:35, 15 November 2023

OCA — Wed, 15 Nov 2023 07:35:23 GMT

←Older revision		Revision as of 07:35, 15 November 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hez is ~~ON HOLD until 2024~~-~~11-09~~	+	==Structure of human SGLT2-MAP17 complex with Dapagliflozin==
-		+	<StructureSection load='8hez' size='340' side='right'caption='[[8hez]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Hiraizumi~~, M., ~~Kishida~~, H., ~~Miyaguchi~~, I., ~~Nureki~~, O.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HEZ FirstGlance]. <br>
-	~~Description~~: ~~Structure of human SGLT2~~-~~MAP17 complex~~ with ~~Dapagliflozin~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LE6:(2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol'>LE6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Nureki, O~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hez OCA], [https://pdbe.org/8hez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hez RCSB], [https://www.ebi.ac.uk/pdbsum/8hez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hez ProSAT]</span></td></tr>
-	[[Category: Kishida, H]]	+	</table>
-	[[Category: Miyaguchi, I]]	+	== Disease ==
-	[[Category: ~~Hiraizumi, M~~]]	+	[https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Familial renal glucosuria. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).[UniProtKB:Q923I7]<ref>PMID:20980548</ref> <ref>PMID:28592437</ref> <ref>PMID:34880493</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Hiraizumi M]]
		+	[[Category: Kishida H]]
		+	[[Category: Miyaguchi I]]
		+	[[Category: Nureki O]]

OCA at 18:41, 12 April 2023

OCA — Wed, 12 Apr 2023 18:41:15 GMT

←Older revision		Revision as of 18:41, 12 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hez is ON HOLD	+	The entry 8hez is ON HOLD until 2024-11-09

-	Authors: ~~Masahiro~~, H., ~~Hioryuki~~, K., ~~Ikuko~~, M., ~~Osamu~~, N.	+	Authors: Hiraizumi, M., Kishida, H., Miyaguchi, I., Nureki, O.

	Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin		Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Hioryuki~~, K]]	+	[[Category: Nureki, O]]
-	[[Category: ~~Masahiro~~, H]]	+	[[Category: Kishida, H]]
-	[[Category: ~~Ikuko~~, M]]	+	[[Category: Miyaguchi, I]]
-	[[Category: ~~Osamu~~, N]]	+	[[Category: Hiraizumi, M]]

OCA at 04:59, 7 April 2023

OCA — Fri, 07 Apr 2023 04:59:44 GMT

←Older revision		Revision as of 04:59, 7 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hez is ON HOLD ~~until 2024-11-09~~	+	The entry 8hez is ON HOLD

	Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N.		Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N.
Line 7:		Line 7:
	Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin		Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ikuko, M]]
-	[[Category: Osamu, N]]
	[[Category: Hioryuki, K]]		[[Category: Hioryuki, K]]
	[[Category: Masahiro, H]]		[[Category: Masahiro, H]]
		+	[[Category: Ikuko, M]]
		+	[[Category: Osamu, N]]

OCA at 06:57, 21 December 2022

OCA — Wed, 21 Dec 2022 06:57:40 GMT

←Older revision		Revision as of 06:57, 21 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hez is ON HOLD	+	The entry 8hez is ON HOLD until 2024-11-09

	Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N.		Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N.
Line 7:		Line 7:
	Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin		Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Hioryuki, K]]
-	[[Category: Masahiro, H]]
	[[Category: Ikuko, M]]		[[Category: Ikuko, M]]
	[[Category: Osamu, N]]		[[Category: Osamu, N]]
		+	[[Category: Hioryuki, K]]
		+	[[Category: Masahiro, H]]

OCA: Protected "8hez" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2022 18:28:48 GMT

Protected "8hez" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:28, 16 November 2022

OCA: New page: '''Unreleased structure''' The entry 8hez is ON HOLD Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N. Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin [[...

OCA — Wed, 16 Nov 2022 18:28:47 GMT

New page: '''Unreleased structure''' The entry 8hez is ON HOLD Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N. Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin [[...

New page

'''Unreleased structure'''

The entry 8hez is ON HOLD

Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N.

Description: Structure of human SGLT2-MAP17 complex with Dapagliflozin
[[Category: Unreleased Structures]]
[[Category: Hioryuki, K]]
[[Category: Masahiro, H]]
[[Category: Ikuko, M]]
[[Category: Osamu, N]]