OCA at 12:04, 6 March 2024

OCA — Wed, 06 Mar 2024 12:04:47 GMT

←Older revision		Revision as of 12:04, 6 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hgz is ~~ON HOLD~~	+	==Crystal structure of insulin==
-		+	<StructureSection load='8hgz' size='340' side='right'caption='[[8hgz]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~Authors~~: ~~DeMirci~~, H., ~~Ayan~~, E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hgz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HGZ FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of insulin	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: Ayan, E]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hgz OCA], [https://pdbe.org/8hgz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hgz RCSB], [https://www.ebi.ac.uk/pdbsum/8hgz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hgz ProSAT]</span></td></tr>
-	[[Category: ~~Demirci,~~ H]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[https://omim.org/entry/176730 176730].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[https://omim.org/entry/125852 125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[https://omim.org/entry/606176 606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[https://omim.org/entry/613370 613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Ayan E]]
		+	[[Category: DeMirci H]]

OCA: Protected "8hgz" [edit=sysop:move=sysop]

OCA — Thu, 24 Nov 2022 08:27:35 GMT

Protected "8hgz" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:27, 24 November 2022

OCA: New page: '''Unreleased structure''' The entry 8hgz is ON HOLD Authors: DeMirci, H., Ayan, E. Description: Crystal structure of insulin Category: Unreleased Structures Category: Ayan, E ...

OCA — Thu, 24 Nov 2022 08:27:34 GMT

New page: '''Unreleased structure''' The entry 8hgz is ON HOLD Authors: DeMirci, H., Ayan, E. Description: Crystal structure of insulin Category: Unreleased Structures Category: Ayan, E ...

New page

'''Unreleased structure'''

The entry 8hgz is ON HOLD

Authors: DeMirci, H., Ayan, E.

Description: Crystal structure of insulin
[[Category: Unreleased Structures]]
[[Category: Ayan, E]]
[[Category: Demirci, H]]

8hgz - Revision history

OCA at 12:04, 6 March 2024

OCA: Protected "8hgz" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8hgz is ON HOLD Authors: DeMirci, H., Ayan, E. Description: Crystal structure of insulin Category: Unreleased Structures Category: Ayan, E ...