8hka - Revision history

OCA at 21:27, 28 June 2023

OCA — Wed, 28 Jun 2023 21:27:03 GMT

←Older revision		Revision as of 21:27, 28 June 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8hka]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ideonella_sakaiensis Ideonella sakaiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HKA FirstGlance]. <br>		<table><tr><td colspan='2'>[[8hka]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ideonella_sakaiensis Ideonella sakaiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HKA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UB7:terephthalic+acid'>UB7</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.02Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UB7:terephthalic+acid'>UB7</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hka OCA], [https://pdbe.org/8hka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hka RCSB], [https://www.ebi.ac.uk/pdbsum/8hka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hka ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hka OCA], [https://pdbe.org/8hka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hka RCSB], [https://www.ebi.ac.uk/pdbsum/8hka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hka ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:40, 21 June 2023

OCA — Wed, 21 Jun 2023 09:40:20 GMT

←Older revision		Revision as of 09:40, 21 June 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hka is ~~ON HOLD until Paper~~ Publication	+	==TPA bound-form of Periplasmic terephthalate binding protein (TBP) from Ideonella sakaiensis==
		+	<StructureSection load='8hka' size='340' side='right'caption='[[8hka]], [[Resolution\|resolution]] 1.02Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8hka]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ideonella_sakaiensis Ideonella sakaiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HKA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UB7:terephthalic+acid'>UB7</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hka OCA], [https://pdbe.org/8hka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hka RCSB], [https://www.ebi.ac.uk/pdbsum/8hka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hka ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0K8P8D2_IDESA A0A0K8P8D2_IDESA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ideonella sakaiensis is the bacterium that can survive by degrading polyethylene terephthalate (PET) plastic, and terephthalic acid (TPA) binding protein (IsTBP) is an essential periplasmic protein for uptake of TPA into the cytosol for complete degradation of PET. Here, we demonstrated that IsTBP has remarkably high specificity for TPA among 33 monophenolic compounds and two 1,6-dicarboxylic acids tested. Structural comparisons with 6-carboxylic acid binding protein (RpAdpC) and TBP from Comamonas sp. E6 (CsTphC) revealed the key structural features that contribute to high TPA specificity and affinity of IsTBP. We also elucidated the molecular mechanism underlying the conformational change upon TPA binding. In addition, we developed the IsTBP variant with enhanced TPA sensitivity, which can be expanded for the use of TBP as a biosensor for PET degradation.

-	~~Authors:~~ Lee, S.H~~., Seo~~, H., Kim, ~~K.-~~J.	+	Molecular mechanism underlying high-affinity terephthalate binding and conformational change of TBP from Ideonella sakaiensis.,Lee SH, Seo H, Hong H, Kim M, Kim KJ Int J Biol Macromol. 2023 Jul 15;243:125252. doi: 10.1016/j.ijbiomac.2023.125252. , Epub 2023 Jun 7. PMID:37295700<ref>PMID:37295700</ref>

-	~~Description: TPA bound-form~~ of ~~Periplasmic terephthalate binding protein (TBP) from~~ Ideonella sakaiensis	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Kim, K.-J]]	+	<div class="pdbe-citations 8hka" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Seo, H~~]]	+	== References ==
-	[[Category: ~~Lee, S.~~H]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ideonella sakaiensis]]
		+	[[Category: Large Structures]]
		+	[[Category: Kim K-J]]
		+	[[Category: Lee SH]]
		+	[[Category: Seo H]]

OCA at 06:59, 21 December 2022

OCA — Wed, 21 Dec 2022 06:59:10 GMT

←Older revision		Revision as of 06:59, 21 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hka is ON HOLD	+	The entry 8hka is ON HOLD until Paper Publication

	Authors: Lee, S.H., Seo, H., Kim, K.-J.		Authors: Lee, S.H., Seo, H., Kim, K.-J.

OCA: Protected "8hka" [edit=sysop:move=sysop]

OCA — Wed, 30 Nov 2022 08:56:35 GMT

Protected "8hka" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:56, 30 November 2022

OCA: New page: '''Unreleased structure''' The entry 8hka is ON HOLD Authors: Lee, S.H., Seo, H., Kim, K.-J. Description: TPA bound-form of Periplasmic terephthalate binding protein (TBP) from Ideonel...

OCA — Wed, 30 Nov 2022 08:56:33 GMT

New page: '''Unreleased structure''' The entry 8hka is ON HOLD Authors: Lee, S.H., Seo, H., Kim, K.-J. Description: TPA bound-form of Periplasmic terephthalate binding protein (TBP) from Ideonel...

New page

'''Unreleased structure'''

The entry 8hka is ON HOLD

Authors: Lee, S.H., Seo, H., Kim, K.-J.

Description: TPA bound-form of Periplasmic terephthalate binding protein (TBP) from Ideonella sakaiensis
[[Category: Unreleased Structures]]
[[Category: Kim, K.-J]]
[[Category: Seo, H]]
[[Category: Lee, S.H]]