8hl6 - Revision history

OCA at 19:51, 29 May 2024

OCA — Wed, 29 May 2024 19:51:12 GMT

←Older revision		Revision as of 19:51, 29 May 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MT21D_HUMAN MT21D_HUMAN] Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97.		[https://www.uniprot.org/uniprot/MT21D_HUMAN MT21D_HUMAN] Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	p97 is a human AAA+ (ATPase associated with diverse cellular activities, also known as valosin-containing protein [VCP]) ATPase, which is involved in diverse cellular processes such as membrane fusion and proteolysis. Lysine-specific methyltransferase of p97 (METTL21D) was identified as a class I methyltransferase that catalyzes the trimethylation of Lys315 of p97, a so-called VCP lysine methyltransferase (VCPKMT). Interestingly, VCPKMT disassembles a single hexamer ring consisting of p97-D1 domain and methylates Lys315 residue. Herein, the structures of S-adenosyl-L-methionine-bound VCPKMT and S-adenosyl-L-homocysteine-bound VCPKMT in complex with p97 N/D1 (N21-Q458) were reported at a resolution of 1.8 A and 2.8 A, respectively. The structures revealed the molecular details for the recognition and methylation of monomeric p97 by VCPKMT. Using biochemical analysis, we also investigated whether the methylation of full-length p97 could be sufficiently enhanced through cooperation between VCPKMT and the C terminus of alveolar soft part sarcoma locus (ASPL). Our study provides the groundwork for future structural and mechanistic studies of p97 and inhibitors.
		+
		+	Structural basis for recognition and methylation of p97 by METTL21D, a valosin-containing protein lysine methyltransferase.,Nguyen TQ, Koh S, Kwon J, Jang S, Kang W, Yang JK iScience. 2023 Jun 26;26(7):107222. doi: 10.1016/j.isci.2023.107222. eCollection , 2023 Jul 21. PMID:37456834<ref>PMID:37456834</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 8hl6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:25, 12 July 2023

OCA — Wed, 12 Jul 2023 07:25:18 GMT

←Older revision		Revision as of 07:25, 12 July 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8hl6 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human valosin-containing protein methyltransferase==
-		+	<StructureSection load='8hl6' size='340' side='right'caption='[[8hl6]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HL6 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hl6 OCA], [https://pdbe.org/8hl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hl6 RCSB], [https://www.ebi.ac.uk/pdbsum/8hl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hl6 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MT21D_HUMAN MT21D_HUMAN] Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Kang W]]
		+	[[Category: Yang JK]]

OCA at 07:58, 14 December 2022

OCA — Wed, 14 Dec 2022 07:58:46 GMT

←Older revision		Revision as of 07:58, 14 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hl6 is ON HOLD	+	The entry 8hl6 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8hl6" [edit=sysop:move=sysop]

OCA — Wed, 07 Dec 2022 05:59:34 GMT

Protected "8hl6" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:59, 7 December 2022

OCA: New page: '''Unreleased structure''' The entry 8hl6 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 07 Dec 2022 05:59:32 GMT

New page: '''Unreleased structure''' The entry 8hl6 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8hl6 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]