OCA at 08:20, 14 June 2023

OCA — Wed, 14 Jun 2023 08:20:10 GMT

←Older revision		Revision as of 08:20, 14 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8hme is ~~ON HOLD until Paper~~ Publication	+	==head module state 1 of Tetrahymena IFT-A==
		+	<StructureSection load='8hme' size='340' side='right'caption='[[8hme]], [[Resolution\|resolution]] 4.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8hme]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HME FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hme OCA], [https://pdbe.org/8hme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hme RCSB], [https://www.ebi.ac.uk/pdbsum/8hme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hme ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q244W3_TETTS Q244W3_TETTS]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Intraflagellar transport (IFT) trains, the polymers composed of two multi-subunit complexes, IFT-A and IFT-B, carry out bidirectional intracellular transport in cilia, vital for cilia biogenesis and signaling. IFT-A plays crucial roles in the ciliary import of membrane proteins and the retrograde cargo trafficking. However, the molecular architecture of IFT-A and the assembly mechanism of the IFT-A into the IFT trains in vivo remains elusive. Here, we report the cryo-electron microscopic structures of the IFT-A complex from protozoa Tetrahymena thermophila. We find that IFT-A complexes present two distinct, elongated and folded states. Remarkably, comparison with the in situ cryo-electron tomography structure of the anterograde IFT train unveils a series of adjustments of the flexible arms in apo IFT-A when incorporated into the anterograde train. Our results provide an atomic-resolution model for the IFT-A complex and valuable insights into the assembly mechanism of anterograde IFT trains.

-	~~Authors: Ma~~, Y., Wu, J., Lei, M.	+	Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train.,Ma Y, He J, Li S, Yao D, Huang C, Wu J, Lei M Nat Commun. 2023 Mar 17;14(1):1506. doi: 10.1038/s41467-023-37208-2. PMID:36932088<ref>PMID:36932088</ref>

-	~~Description: head module state 1~~ of ~~Tetrahymena IFT~~-A	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Wu, J~~]]	+	<div class="pdbe-citations 8hme" style="background-color:#fffaf0;"></div>
-	[[Category: Ma, Y]]	+	== References ==
-	[[Category: ~~Lei, M~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Tetrahymena thermophila]]
		+	[[Category: Lei M]]
		+	[[Category: Ma Y]]
		+	[[Category: Wu J]]

OCA at 07:00, 21 December 2022

OCA — Wed, 21 Dec 2022 07:00:12 GMT

←Older revision		Revision as of 07:00, 21 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hme is ON HOLD	+	The entry 8hme is ON HOLD until Paper Publication

	Authors: Ma, Y., Wu, J., Lei, M.		Authors: Ma, Y., Wu, J., Lei, M.
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	Description: head module state 1 of Tetrahymena IFT-A		Description: head module state 1 of Tetrahymena IFT-A
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Lei, M]]
	[[Category: Wu, J]]		[[Category: Wu, J]]
	[[Category: Ma, Y]]		[[Category: Ma, Y]]
		+	[[Category: Lei, M]]

OCA: Protected "8hme" [edit=sysop:move=sysop]

OCA — Wed, 14 Dec 2022 08:00:32 GMT

Protected "8hme" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 14 December 2022

OCA: New page: '''Unreleased structure''' The entry 8hme is ON HOLD Authors: Ma, Y., Wu, J., Lei, M. Description: head module state 1 of Tetrahymena IFT-A Category: Unreleased Structures [[Catego...

OCA — Wed, 14 Dec 2022 08:00:28 GMT

New page: '''Unreleased structure''' The entry 8hme is ON HOLD Authors: Ma, Y., Wu, J., Lei, M. Description: head module state 1 of Tetrahymena IFT-A Category: Unreleased Structures [[Catego...

New page

'''Unreleased structure'''

The entry 8hme is ON HOLD

Authors: Ma, Y., Wu, J., Lei, M.

Description: head module state 1 of Tetrahymena IFT-A
[[Category: Unreleased Structures]]
[[Category: Lei, M]]
[[Category: Wu, J]]
[[Category: Ma, Y]]

8hme - Revision history

OCA at 08:20, 14 June 2023

OCA at 07:00, 21 December 2022

OCA: Protected "8hme" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8hme is ON HOLD Authors: Ma, Y., Wu, J., Lei, M. Description: head module state 1 of Tetrahymena IFT-A Category: Unreleased Structures [[Catego...