OCA at 10:01, 20 December 2023

OCA — Wed, 20 Dec 2023 10:01:16 GMT

←Older revision		Revision as of 10:01, 20 December 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8ho4 is ~~ON HOLD until 2024~~-12-09	+	==Falcilysin in complex with MMV000848==
-		+	<StructureSection load='8ho4' size='340' side='right'caption='[[8ho4]], [[Resolution\|resolution]] 1.96Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ho4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HO4 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.96Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=XUH:(2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol'>XUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ho4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ho4 OCA], [https://pdbe.org/8ho4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ho4 RCSB], [https://www.ebi.ac.uk/pdbsum/8ho4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ho4 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FCLN_PLAF7 FCLN_PLAF7] In the food vacuole, acts downstream of proteases plasmepsins PMI and PMII and falcipains during the catabolism of host hemoglobin by cleaving peptide fragments of alpha and beta hemoglobin subunits generated by PMI and PMII and falcipains (PubMed:17074076). In the apicoplast, degrades apicoplast transit peptides after their cleavage (PubMed:17074076). Prefers bulky hydrophobic amino acids in the P1' position at both acidic and neutral pH (By similarity). At P2', prefers hydrophobic residues at acidic pH; at neutral pH, these same residues are abundant but prefers Arg (By similarity). At P3', prefers hydrophobic residues, especially Met, at both pH conditions. At P4' and P5', prefers acidic residues at acidic pH, however, at neutral pH, the enzyme is less selective at these positions (By similarity). The optimal site cleavage at acidic pH is YNEHS-\|-FFMEE and, at neutral pH, MKRHS-\|-FRMRG (By similarity).[UniProtKB:A0A0L7KF24]<ref>PMID:17074076</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Plasmodium falciparum 3D7]]
		+	[[Category: Chung Z]]
		+	[[Category: Lescar J]]
		+	[[Category: Lin JQ]]

OCA at 07:02, 21 December 2022

OCA — Wed, 21 Dec 2022 07:02:36 GMT

←Older revision		Revision as of 07:02, 21 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ho4 is ON HOLD	+	The entry 8ho4 is ON HOLD until 2024-12-09

	Authors:		Authors:

OCA: Protected "8ho4" [edit=sysop:move=sysop]

OCA — Wed, 14 Dec 2022 08:07:10 GMT

Protected "8ho4" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:07, 14 December 2022

OCA: New page: '''Unreleased structure''' The entry 8ho4 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Dec 2022 08:07:09 GMT

New page: '''Unreleased structure''' The entry 8ho4 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ho4 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8ho4 - Revision history

OCA at 10:01, 20 December 2023

OCA at 07:02, 21 December 2022

OCA: Protected "8ho4" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ho4 is ON HOLD Authors: Description: Category: Unreleased Structures