8hpo - Revision history

OCA at 05:55, 5 July 2023

OCA — Wed, 05 Jul 2023 05:55:51 GMT

←Older revision		Revision as of 05:55, 5 July 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8hpo]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HPO FirstGlance]. <br>		<table><tr><td colspan='2'>[[8hpo]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HPO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hpo OCA], [https://pdbe.org/8hpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hpo RCSB], [https://www.ebi.ac.uk/pdbsum/8hpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hpo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hpo OCA], [https://pdbe.org/8hpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hpo RCSB], [https://www.ebi.ac.uk/pdbsum/8hpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hpo ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:33, 3 May 2023

OCA — Wed, 03 May 2023 07:33:43 GMT

←Older revision		Revision as of 07:33, 3 May 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hpo is ~~ON HOLD~~	+	==Cryo-EM structure of a SIN3/HDAC complex from budding yeast==
		+	<StructureSection load='8hpo' size='340' side='right'caption='[[8hpo]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8hpo]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HPO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hpo OCA], [https://pdbe.org/8hpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hpo RCSB], [https://www.ebi.ac.uk/pdbsum/8hpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hpo ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UME1_YEAST UME1_YEAST] Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.<ref>PMID:12954623</ref> <ref>PMID:16286008</ref> <ref>PMID:9234739</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SIN3-HDAC (histone deacetylases) complexes have important roles in facilitating local histone deacetylation to regulate chromatin accessibility and gene expression. Here, we present the cryo-EM structure of the budding yeast SIN3-HDAC complex Rpd3L at an average resolution of 2.6 A. The structure reveals that two distinct arms (ARM1 and ARM2) hang on a T-shaped scaffold formed by two coiled-coil domains. In each arm, Sin3 interacts with different subunits to create a different environment for the histone deacetylase Rpd3. ARM1 is in the inhibited state with the active site of Rpd3 blocked, whereas ARM2 is in an open conformation with the active site of Rpd3 exposed to the exterior space. The observed asymmetric architecture of Rpd3L is different from those of available structures of other class I HDAC complexes. Our study reveals the organization mechanism of the SIN3-HDAC complex and provides insights into the interaction pattern by which it targets histone deacetylase to chromatin.

-	~~Authors~~:	+	Structure of a SIN3-HDAC complex from budding yeast.,Guo Z, Chu C, Lu Y, Zhang X, Xiao Y, Wu M, Gao S, Wong CCL, Zhan X, Wang C Nat Struct Mol Biol. 2023 Apr 20. doi: 10.1038/s41594-023-00975-z. PMID:37081318<ref>PMID:37081318</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8hpo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Saccharomyces cerevisiae S288C]]
		+	[[Category: Guo Z]]
		+	[[Category: Wang C]]
		+	[[Category: Zhan X]]

OCA: Protected "8hpo" [edit=sysop:move=sysop]

OCA — Wed, 21 Dec 2022 07:10:27 GMT

Protected "8hpo" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:10, 21 December 2022

OCA: New page: '''Unreleased structure''' The entry 8hpo is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 21 Dec 2022 07:10:24 GMT

New page: '''Unreleased structure''' The entry 8hpo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8hpo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]