OCA at 10:02, 20 December 2023

OCA — Wed, 20 Dec 2023 10:02:26 GMT

←Older revision		Revision as of 10:02, 20 December 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8htg is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Golf in complex with GTP-gamma S and Mg==
		+	<StructureSection load='8htg' size='340' side='right'caption='[[8htg]], [[Resolution\|resolution]] 2.91Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8htg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HTG FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.91Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8htg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8htg OCA], [https://pdbe.org/8htg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8htg RCSB], [https://www.ebi.ac.uk/pdbsum/8htg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8htg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAL_MOUSE GNAL_MOUSE] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structural and mechanistic studies on human odorant receptors (ORs), key in olfactory signaling, are challenging because of their low surface expression in heterologous cells. The recent structure of OR51E2 bound to propionate provided molecular insight into odorant recognition, but the lack of an inactive OR structure limited understanding of the activation mechanism of ORs upon odorant binding. Here, we determined the cryo-electron microscopy structures of consensus OR52 (OR52(cs)), a representative of the OR52 family, in the ligand-free (apo) and octanoate-bound states. The apo structure of OR52(cs) reveals a large opening between transmembrane helices (TMs) 5 and 6. A comparison between the apo and active structures of OR52(cs) demonstrates the inward and outward movements of the extracellular and intracellular segments of TM6, respectively. These results, combined with molecular dynamics simulations and signaling assays, shed light on the molecular mechanisms of odorant binding and activation of the OR52 family.

-	~~Authors~~:	+	Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family.,Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ Nat Commun. 2023 Dec 7;14(1):8105. doi: 10.1038/s41467-023-43983-9. PMID:38062020<ref>PMID:38062020</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8htg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Choi H-J]]
		+	[[Category: Kang H]]

OCA at 09:35, 1 February 2023

OCA — Wed, 01 Feb 2023 09:35:39 GMT

←Older revision		Revision as of 09:35, 1 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8htg is ON HOLD	+	The entry 8htg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8htg" [edit=sysop:move=sysop]

OCA — Wed, 28 Dec 2022 06:34:30 GMT

Protected "8htg" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:34, 28 December 2022

OCA: New page: '''Unreleased structure''' The entry 8htg is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Dec 2022 06:34:25 GMT

New page: '''Unreleased structure''' The entry 8htg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8htg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8htg - Revision history

OCA at 10:02, 20 December 2023

OCA at 09:35, 1 February 2023

OCA: Protected "8htg" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8htg is ON HOLD Authors: Description: Category: Unreleased Structures