8hun - Revision history

OCA at 10:10, 6 September 2023

OCA — Wed, 06 Sep 2023 10:10:12 GMT

←Older revision		Revision as of 10:10, 6 September 2023
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>		[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
		+
		+	==See Also==
		+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:29, 9 August 2023

OCA — Wed, 09 Aug 2023 05:29:16 GMT

←Older revision		Revision as of 05:29, 9 August 2023
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-	'''Unreleased structure'''

-	~~The~~ entry 8hun is ~~ON HOLD until Paper Publication~~	+	==PDB entry title: X-ray structure of human PPAR alpha ligand binding domain-seladelpar co-crystals obtained by cross-seeding==
-		+	<StructureSection load='8hun' size='340' side='right'caption='[[8hun]], [[Resolution\|resolution]] 2.01Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HUN FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KKB:Seladelpar'>KKB</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hun OCA], [https://pdbe.org/8hun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hun RCSB], [https://www.ebi.ac.uk/pdbsum/8hun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hun ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Honda A]]
		+	[[Category: Iino S]]
		+	[[Category: Ishii I]]
		+	[[Category: Kamata S]]
		+	[[Category: Machida Y]]
		+	[[Category: Masuda R]]
		+	[[Category: Oyama T]]
		+	[[Category: Shiiyama Y]]
		+	[[Category: Uchii K]]

OCA at 05:22, 8 February 2023

OCA — Wed, 08 Feb 2023 05:22:56 GMT

←Older revision		Revision as of 05:22, 8 February 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hun is ON HOLD	+	The entry 8hun is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8hun" [edit=sysop:move=sysop]

OCA — Wed, 11 Jan 2023 06:11:22 GMT

Protected "8hun" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:11, 11 January 2023

OCA: New page: '''Unreleased structure''' The entry 8hun is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Jan 2023 06:11:21 GMT

New page: '''Unreleased structure''' The entry 8hun is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8hun is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]